Results 191 to 200 of about 349,410 (289)

Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy

Macromolecular Rapid Communications, EarlyView.
Sulfonium‐based antimicrobial block copolymers combine an active cationic hydrophobic block with a neutral hydrophilic block to improve cytocompatibility. The hydrophobicity of the sulfonium‐based block controls the activity against S. aureus and E coli.
Sidra Kanwal, Otto Staudhammer, Umer Bin Abdul Aziz, Elisa Quaas, Jörg Rademann, Daniel Klinger   +5 more
wiley   +1 more source

Reversing ABCB1-Mediated Multidrug Resistance in Colorectal Cancer: electroacupuncture shows therapeutic potential <i>in vivo</i>. [PDF]

J Pharmacopuncture
Qiu Y, Fan Z, Qi X, Jiang H, Zhao W, Wan Y, Huang J.   +6 more
europepmc   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand. [PDF]

Sci Rep
Opassathian K, Boonmee N, Swangkaew S, Jenjaroenpun P, Wongsurawat T, Kruasuwan W, Ngamskulrungroj P, Mitrpant C.   +7 more
europepmc   +1 more source

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

Nanoengineered photosensitizers for photodynamic priming to overcome P-glycoprotein-mediated multidrug resistance. [PDF]

Photochem Photobiol
Rahman I, Meda A, Moore KA, Srivastava P, Dasgupta A, Sajid A, Ambudkar SV, Huang HC.   +7 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Antimicrobial multidrug resistance of Escherichia coli from broiler farms in Zhanjiang, China. [PDF]

PLoS One
Liao C, Peng J, Luo S, Xie X, Li Y, Ma H, Yu M, Ding Y, Ma Y.   +8 more
europepmc   +1 more source

The Expanding Landscape of Microbiota Medicine: Indications, Therapeutic Modalities, and the Path Towards Integrative Microbiome‐Targeting Healthcare

Microbiota Medicine Research, EarlyView.
ABSTRACT The growing recognition of the microbiome's role in human health has propelled the emergence of microbiota medicine—a new discipline integrating microbiology, multi‐omics, and clinical science. Advances in sequencing, data integration, and interventions such as fecal microbiota transplantation (FMT) have transitioned the field from ...
Min Dai, Yisha Lin, Renyou Gan, Xiaotao Shen, Shin Young Park, Sunjae Lee, Qi Su   +6 more
wiley   +1 more source