Results 211 to 220 of about 234,319 (307)

Sulfonium‐Based Antimicrobial Block Copolymers: Influence of Hydrophobicity on Biological Activity and Antibiotic Synergy

Macromolecular Rapid Communications, EarlyView.
Sulfonium‐based antimicrobial block copolymers combine an active cationic hydrophobic block with a neutral hydrophilic block to improve cytocompatibility. The hydrophobicity of the sulfonium‐based block controls the activity against S. aureus and E coli.
Sidra Kanwal, Otto Staudhammer, Umer Bin Abdul Aziz, Elisa Quaas, Jörg Rademann, Daniel Klinger   +5 more
wiley   +1 more source

Convergence of multidrug resistance with biofilm formation and hypermucoviscosity in <i>Klebsiella pneumoniae</i> from tertiary-care hospitals in Northwestern Pakistan. [PDF]

Antimicrob Steward Healthc Epidemiol
Waheed A, Khan TA, Ahmad S, Ahmed F, Khan Z.   +4 more
europepmc   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Plasmid-mediated convergence of multidrug resistance and hypervirulence in community-acquired Klebsiella pneumoniae in Tianjin, China. [PDF]

BMC Microbiol
Li D, Fan Z, Wang S, Su Y, Yuan M, Fang H, Wang R, Gao H, Bai H, Mao D, Luo Y.   +10 more
europepmc   +1 more source

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

Biofilm-associated antibiotic tolerance in the era of multidrug resistance: quorum-sensing mechanisms and emerging therapeutic strategies. [PDF]

Front Cell Infect Microbiol
Subramani T, George EA, Saju AE, E M, De R, K SA, Ramaiah S, Anbarasu A.   +7 more
europepmc   +1 more source

Cefdinir reprograms Gram‐positive bacteria to synergize with lysozyme against superbugs

mLife, EarlyView.
Abstract Multidrug‐resistant (MDR) bacteria pose a critical global health threat, urgently requiring solutions. Cefdinir, the highest‐selling third‐generation cephalosporin but one now facing clinical obsolescence due to escalating resistance, is conventionally classified as a nascent cell wall synthesis inhibitor.
Qi Zhang, Yang Yang, Shuqi Li, Zhao Liu, Chun‐Kit Lee, Chi‐Bun Ko, Qian Zhao   +6 more
wiley   +1 more source

Incidence and outcomes for colonization of multidrug-resistance organisms (MDROs) among patients undergoing elective orthopedic surgery. [PDF]

Antimicrob Steward Healthc Epidemiol
Umpunthongsiri S, Apisarnthanarak A, Srimanote P, Khawcharoenporn T, Aungthong C, Mungkornkaew N, Damronglerd P, Rutjanawech S, Suwantarat N.   +8 more
europepmc   +1 more source

Rapid and quantitative phage susceptibility test by ramanome

mLife, EarlyView.
Abstract Antimicrobial resistance poses an escalating global threat, renewing interest in bacteriophage therapy as a precision alternative to antibiotics. However, clinical translation remains hindered by the lack of rapid and quantitative phage susceptibility testing (PST) platforms capable of evaluating host range, infection potency, and effective ...
Xiao Han, Xiaofu Wan, Yang Zhou, Xiaoting Fu, Xiaoshan Zheng, Bo Gao, Shi Huang, Anle Ge, Jiadong Huang, Hongzhou Lu, Jian Xu   +10 more
wiley   +1 more source

Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer [Retraction]. [PDF]

Int J Nanomedicine
europepmc   +1 more source