Results 231 to 240 of about 235,517 (308)

Multifunctional Nanodiamond Conjugate With a Tumor‐Specific EGFR‐Targeting Peptide and Photoactivated CO Release for Improved Therapeutic Efficacy in Head and Neck Cancers

open access: yesSmall, EarlyView.
A multifunctional nanodiamond conjugate carrying a blue light‐activated carbon monoxide‐releasing molecule and an EGFR‐targeting peptide enables efficient, targeted CO delivery in vitro and in vivo. Upon photoactivation, the particles induce cancer‐specific cytotoxicity and significantly suppress tumor growth and lymph node metastasis in a head and ...
Harsh Nitin Dongre   +12 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

open access: yesSmall, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen   +9 more
wiley   +1 more source

Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms

open access: yesThe Chemical Record, EarlyView.
Additive manufacturing enables the rational design of structured antimicrobial platforms across multiple length scales, from nanofibrous scaffolds and droplet microreactors to 3D and 4D printed constructs. By engineering confinement, interfacial chemistry, and stimuli‐responsive release, these systems exert localized action through complementary ...
Giorgia Puleo   +11 more
wiley   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye   +5 more
wiley   +1 more source

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