Results 261 to 270 of about 235,517 (308)
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Doxorubicin and multidrug resistance
Current Opinion in Oncology, 1993The circumvention of P-glycoprotein function by pharmacologic agents is a major focus of clinical trials aimed at increasing the cytotoxicity of multidrug resistance-associated drugs, including doxorubicin. The success of this approach will likely depend on the clinical significance of P-glycoprotein expression, which has not yet been elucidated for ...
G D, Kruh, L J, Goldstein
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Der Urologe A, 1996
The past decade has seen the successful application of genetic techniques in the dissection of the most important phenotypes of cancer cells. In the case of drug resistance mechanisms, the elucidation of the genes involved in resistance to anticancer agents has led to new and unexpected information about tumor physiology and may well open therapeutic ...
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The past decade has seen the successful application of genetic techniques in the dissection of the most important phenotypes of cancer cells. In the case of drug resistance mechanisms, the elucidation of the genes involved in resistance to anticancer agents has led to new and unexpected information about tumor physiology and may well open therapeutic ...
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The reversal of multidrug resistance
1995The failure of chemotherapy to achieve complete and durable responses has been attributed in large part to the phenomenon of drug resistance. In the laboratory, tumor cells can be selected for resistance to a particular cytotoxin by repeated exposure to that drug.
G A, Fisher, B L, Lum, B I, Sikic
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Multidrug Resistance in Plague
New England Journal of Medicine, 1997Untreated, human plague is often fulminant and fatal,1 which reinforces its historical reputation as a devastating disease. Plague is a zoonosis of rodents and their fleas caused by Yersinia pestis, a member of the family Enterobacteriaceae. People are usually infected by bites from fleas found on rodents, occasionally by direct contact with infectious
D T, Dennis, J M, Hughes
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Multidrug Resistance in Leukaemia
Leukemia & Lymphoma, 1990The treatment of many haematological malignancies is complicated by the development of resistance to cytotoxic agents. Cells which acquire the multidrug resistant (MDR) phenotype lose sensitivity to a spectrum of structurally unrelated chemotherapeutic drugs.
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Multidrug resistance in leukemia
1993Over the last 20 years, advances in chemotherapy have improved the outcome in a number of cancers, most notably in the acute leukemias, lymphomas, testicular carcinoma, and several pediatric malignancies. Despite the advances in the treatment of the acute leukemias with very high remission rates to initial chemotherapy and significant cure rates, many ...
D, Rischin, V, Ling
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Multidrug-resistant tuberculosis
Clinica Chimica ActaOne of predominant contributors to global mortality is tuberculosis (TB), an infection caused by Mycobacterium tuberculosis (MTB). Inappropriate and ineffectual treatment can lead to the development of drug-resistant TB. One of the most common forms of drug-resistant TB is multidrug-resistant tuberculosis (MDR-TB), caused by mutations in the rpoB and ...
Dika Apriliana, Wulandari +4 more
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Inhibitors of multidrug resistance
Current Opinion in Oncology, 1997P-glycoprotein expression on tumor cells is a frequent cause of pleiotropic drug resistance in cell lines and tumor specimens. Besides the multidrug resistance gene (MDR1), other mechanisms of increased drug extrusion have been described, such as the MDR-related protein and the lung resistance protein.
Sonneveld, Pieter, Wiemer, Erik
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Multidrug resistance in leukemia
Current Opinion in Hematology, 1998Resistance of tumors to chemotherapeutic agents is an important factor that limits the successful treatment of a wide range of malignancies. The multidrug resistant (MDR) phenotype is well recognized in clinical samples, and it has been extensively studied, particularly in acute myeloid leukemia.
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Multidrug Resistance in Cancer
Scientific American, 1989Chemotherapy often fails because a tumor develops resistance to an array of different drugs. A single glycoprotein turns out to be responsible: it proliferates in some cells and pumps out the drugs. Now that the protein pump has been identified it may be possible to interfere with its action or to make it the target for drugs that destroy the cancer ...
N, Kartner, V, Ling
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