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Multidrug Resistance in Anaerobes
Future Microbiology, 2019Multidrug resistance (MDR) in anaerobes is not a well-known topic. Bacteroides fragilis group isolates have numerous resistance determinants such as multidrug efflux pumps, cfiA and nimB genes and activating insertion sequences, and some isolates exhibited extensive drug-resistant patterns. MDR rates in B. fragilis group were from 1.5 to >18% and up to
Lyudmila Boyanova +2 more
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Inhibitors of multidrug resistance
Current Opinion in Oncology, 1997P-glycoprotein expression on tumor cells is a frequent cause of pleiotropic drug resistance in cell lines and tumor specimens. Besides the multidrug resistance gene (MDR1), other mechanisms of increased drug extrusion have been described, such as the MDR-related protein and the lung resistance protein.
Sonneveld, Pieter, Wiemer, Erik
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Multidrug-Resistance Transporters
2002P-glycoprotein was initially isolated due to its role in multidrug resistance to cancer chemotherapeutics. Recent work, however, makes it increasingly apparent that this transporter is also involved in the pharmacokinetics of many drugs. P-gp is strategically expressed in the luminal epithelial cells of organs often associated with drug absorption and ...
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Multidrug resistance in leukaemia
Baillière's Clinical Haematology, 1992Multidrug resistance hampers successful chemotherapy in many haematological neoplasms and is mediated by several cellular proteins. In some cases, the genes encoding these proteins have been shown to confer resistance on transfer to drug-sensitive cell lines. This is true for the efflux pump product of the MDR1 gene, P-170. Upregulation of enzymes such
P, Baines, P, Cumber, R A, Padua
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Reversal of Multidrug Resistance
Journal of Hematotherapy, 1994S E, Bates +7 more
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MULTIDRUG RESISTANCE IN LEUKAEMIA
British Journal of Haematology, 1997S L, McKenna, R A, Padua
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Multidrug-resistant tuberculosis
Infectious Disease Clinics of North America, 2002Multidrug-resistant TB is a growing public health problem. Although control of the multidrug-resistant TB epidemic has been achieved in New York City, strains of multidrug-resistant TB are found in nearly every state. Much of the world faces a growing problem with no immediate solution.
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Mechanism of multidrug resistance
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1988G, Bradley, P F, Juranka, V, Ling
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