Results 81 to 90 of about 846,511 (205)

Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure developmentResearch in context

EBioMedicine
Summary: Background: Quantitating the contribution of phenotype-responsible elements in hypervirulent Klebsiella pneumoniae is needed. Methods: Isogenic mutants of four hypervirulent clinical isolates that produced K1 (ST23), K2 (ST86), K20 (ST1544), or
Thomas A. Russo, Ulrike Carlino-MacDonald, Zachary J. Drayer, Connor J. Davies, Cassandra L. Alvarado, Alan Hutson, Ting L. Luo, Melissa J. Martin, Patrick T. McGann, Francois Lebreton   +9 more
doaj   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea [PDF]

, 2012
: BACKGROUND: Monitoring drug resistance in Mycobacterium tuberculosis is essential to curb the spread of tuberculosis (TB). Unfortunately, drug susceptibility testing is currently not available in Papua New Guinea (PNG) and that impairs TB control in ...
Gagneux, S., Siba Peter, Beck, H. P., Hans-Peter Beck, Beck Hans-Peter, Carter Robyn, Paul Harino, Harino, P., Carter, R., Serej Ley, Ley Serej, Siba, P., Gagneux Sebastien, Borrell Sonia, Coscolla Mireia, Mireia Coscolla, Ballif Marie, Stefan Niemann, Ley, S., Marie Ballif, Coulter, C., Robyn Carter, Coulter Christopher, Christopher Coulter, Ballif, M., Peter Siba, Niemann, S., Harino Paul, Niemann Stefan, Sebastien Gagneux, Phuanukoonnon, S., Borrell, S., Coscolla, M., Sonia Borrell, Suparat Phuanukoonnon, Phuanukoonnon Suparat   +35 more
core   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Gut microbiota-driven immunomodulation in tuberculosis: targeting dysbiosis to overcome drug resistance

Frontiers in Immunology
Tuberculosis (TB) remains a major global health threat, hampered by the escalating prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Qi Nie, Qi Nie, Xujuan Hu, Xujuan Hu, Yingjie Zhang, Yingjie Zhang, Ling Pan, Ling Pan, Xiaoqing Zhang, Xiaoqing Zhang, Yong Zhou, Yong Zhou, Tingting Fu, Tingting Fu, Lijuan Zheng, Lijuan Zheng, Fan Xiao, Fan Xiao, Yuan Liu, Yuan Liu, Si Du, Si Du, Jieguang Liu, Jieguang Liu, Leyiyi Liu, Leyiyi Liu, Xianglian Xiong, Xianglian Xiong, Yuanjun Wu, Yuanjun Wu, Dan Fan, Dan Fan, Lixuan Tao, Fuli Ren, Fuli Ren, Fuli Ren   +35 more
doaj   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Diagnostic value of the combined test of leukocytes in urine and TB-DOT and T-SPOT.TB in blood for urinary tuberculosis

Frontiers in Microbiology
BackgroundThis study aims to evaluate the clinical utility of routine urinary tests and renal function assessments, as well as the Tuberculosis antibody test (TB-DOT) and T-cell spot tests for TB infection (T-SPOT.TB), either individually or in ...
Yanyan Li, Yanyan Li, Yanyan Li, Yanyan Li, Yanyan Li, Yachun Wang, Yachun Wang, Yachun Wang, Yachun Wang, Yachun Wang, Lukuan Wei, Lukuan Wei, Lukuan Wei, Lukuan Wei, Lukuan Wei, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang   +19 more
doaj   +1 more source

Multidrug-resistant tuberculosis in children and response to therapy

Medical Journal of Dr. D.Y. Patil University, 2015
There is very little information available on drug-resistant (DR) tuberculosis (TB) in children in Indian scenario and especially their response to therapy. We present a series of children who were suffering from multidrug-resistant-TB and their response
Ira Shah
doaj   +1 more source

[The long term (9-year) survival of multidrug-resistant tuberculosis patients compared to non-multidrug-resistant tuberculosis patients in Henan province].

, 2013
[The long term (9-year) survival of multidrug-resistant tuberculosis patients compared to non-multidrug-resistant tuberculosis patients in Henan province]
G Hall (3596234), A Sleigh (13383024), XA Zhen (15839027), GJ Wang (15839024), Hassan Vally (13074096), YN Sun (15839021), D Harley (13383021), ZF Liu (14594543)   +7 more
core  

Molecular Docking of Multidrug Resistant Klebsiella pneumoniae from River Water of Klang Valley, Malaysia

, 2019
Malaysia Klang River covering states of Selangor and Kuala Lumpur, has been severely polluted from urbanization, industrialization and increased hospitals.
Ponmurugan P., Balavinayagamani Ganapathy, Gnanendra Shanmugam, Sridevi Subramonie, Venkatasathya Sai Appala Raju Velaga, Yoke Ing Kwan, Nagaraja Suryadevara   +6 more
core   +1 more source