How evolution dismantles and reassembles multienzyme complexes. [PDF]
Proc Natl Acad Sci U S A, 2022 The mycobacterial PDH features an unusual architecture that may allow it to function in combination with otherα-ketoacid dehydrogenase complexes.
Mattevi A.
europepmc +5 more sources
Nuclear Magnetic Resonance Approaches in the Study of 2-Oxo Acid Dehydrogenase Multienzyme Complexes—A Literature Review [PDF]
Molecules, 2013 The 2-oxoacid dehydrogenase complexes (ODHc) consist of multiple copies of three enzyme components: E1, a 2-oxoacid decarboxylase; E2, dihydrolipoyl acyl-transferase; and E3, dihydrolipoyl dehydrogenase, that together catalyze the oxidative ...
Mulchand S. Patel +2 more
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Nature-inspired confined cascade enzyme nanoreactors for targeted atherosclerosis therapy [PDF]
Signal Transduction and Targeted TherapyOxidative stress and excessive inflammatory responses are major drivers of atherosclerosis (AS) formation and progression. In this study, we report a nature-inspired nanoreactor (named USPB@SeDMSN@NM) with superoxide dismutase (SOD), catalase (CAT), and ...
Yuehuang Wu +7 more
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Comparison study between single enzyme and multienzyme complex in distiller’s dred grains with soluble supplemented diet in broiler chicken [PDF]
Journal of Animal Science and TechnologyUpregulation of the nutritional value of feed is the major target of various studies in the livestock industry, and dietary enzyme supplementation could aid in digesting the nondegrading nutrients of grains in feed ingredients.
Min-Jin Kwak +5 more
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Mer overexpression in Methanosarcina acetivorans affects growth and methanogenesis during substrate adaptation [PDF]
Applied and Environmental MicrobiologyEvidence suggests that multienzyme complexes are involved in biological methane production (methanogenesis), although the composition of the Wolfe Cycle methanogenesis complexes may vary between diverse methanoarchaeal taxa ...
Darla Brennan +4 more
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Functional characterization of a dockerin-containing expansin-like protein from the anaerobic fungus Neocallimastix californiae [PDF]
Biotechnology for Biofuels and BioproductsBackground Anaerobic microbes produce multienzyme complexes known as cellulosomes to enhance the degradation of cellulosic substrates. These complexes localize diverse enzymes onto a protein scaffold, where proteins are anchored by dockerin domains ...
Taru Koitto +5 more
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Screening of novel β-carotene hydroxylases for the production of β-cryptoxanthin and zeaxanthin and the impact of enzyme localization and crowding on their production in Yarrowia lipolytica [PDF]
Microbial Cell FactoriesZeaxanthin, a vital dietary carotenoid, is naturally synthesized by plants, microalgae, and certain microorganisms. Large-scale zeaxanthin production can be achieved through plant extraction, chemical synthesis, or microbial fermentation.
Mladen Soldat +8 more
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Fine tuning of spatial arrangement of enzymes in a PCNA-mediated multienzyme complex using a rigid poly-L-proline linker. [PDF]
PLoS ONE, 2013 Inspired by natural multienzyme complexes, many types of artificial multienzyme complexes have recently been constructed. We previously constructed a self-assembled complex of a bacterial cytochrome P450 and its ferredoxin and ferredoxin reductase ...
Tomoaki Haga +2 more
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Photosynthetic Electron Transfer by Dint of Protein Mobile Carriers. Multi-particle Brownian and Molecular Modeling [PDF]
EPJ Web of Conferences, 2019 The paper presents the review of works on modeling the interaction of photosynthetic proteins using the multiparticle Brownian dynamics method developed at the Department of Biophysics, Biological Faculty, Lomonosov Moscow State University.
Riznichenk Galina +4 more
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Application of artificial scaffold systems in microbial metabolic engineering
Frontiers in Bioengineering and Biotechnology, 2023 In nature, metabolic pathways are often organized into complex structures such as multienzyme complexes, enzyme molecular scaffolds, or reaction microcompartments. These structures help facilitate multi-step metabolic reactions.
Nana Liu +6 more
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