Results 91 to 100 of about 6,631,648 (289)

The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase. [PDF]

, 1988
Autoantibodies to mitochondrial antigens are characteristic of the autoimmune liver disease primary biliary cirrhosis (PBC), but the precise antigenic determinants recognized by these antibodies have not been defined.
Ansari, A, Coppel, R, Gershwin, M, Leung, P, Van De Water, Judith   +4 more
core  

Hydrogel Composites and Their Potential Application in Animal Production and Health

Animal Research and One Health, EarlyView.
With emerging concerns about environmental contamination and safe animal production practices for increased animal welfare, research has increased in search of alternatives to promote sustainable production. The application of naturally derived hydrogels presents a great opportunity for exploration and application for animal production purposes ...
Victoria Anthony Uyanga, Tolulope Grace Ogundipe, Onome Ejeromedoghene, Abigail Adamma Ere‐Richard, Edikan Effiong Okon   +4 more
wiley   +1 more source

An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]

, 1996
A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N., Dougherty, Dennis A., Du, Fangyong, Kearney, Patrick C., Lester, Henry A., Nowak, Mark W., Saks, Margaret E., Sampson, Jeffrey R.   +7 more
core   +1 more source

Defect‐engineered iron single‐site catalysts with tailored atomic coordination for enhanced mild photothermal therapy via triad modulation of apoptosis and ferroptosis

BMEMat, EarlyView.
A defect‐engineered triad catalyst (DMOF‐SNP‐siRNA) has been developed to enhance mild photothermal therapy for cancer treatment by addressing the limitations of heat shock protein overexpression and suboptimal therapeutic outcomes. This synergy induces potent apoptotic and ferroptotic responses, significantly enhancing the photothermal and catalytic ...
Fanghua Zhang, Wendong Liu, Zhe Hao, Haijun Lu, Jinzheng Liu, Huajie Pang, Ruizhong Zhang, Xiyan Li, Zongjie Wang, Libing Zhang   +9 more
wiley   +1 more source

Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases [PDF]

, 2018
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains ...
A Keatinge-Clay, AG Palmer III., Andrew S Barrow, AS Worthington, AS Worthington, AT Keatinge-Clay, AT Keatinge-Clay, BG Pierce, C Hertweck, CD Richter, Daniel Griffiths, DT Wagner, DT Wagner, E Lescop, EJN Helfrich, FH Schumann, GM Pavlović-Lažetić, Gregory L Challis, J Bellay, J Dorival, J Kuo, J Nilsson, J Yang, J Zeng, JG Lees, JL Meier, John E Moses, Józef R Lewandowski, KJ Weissman, L Gitlin, L Katz, L Manzi, L Song, L Whitmore, LJ McGuffin, Lucio Manzi, MA Fischbach, MA Larkin, Matthew Jenner, MP Williamson, MR Jensen, Neil J Oldham, Panward Prasongpholchai, PE Wright, RS Gokhale, RW Broadhurst, S Kapur, S Kosol, S Vucetic, Simone Kosol, SR Eddy, TJ Buchholz, V Neduva, VB Chen, VN Uversky, WF Vranken, YS Lin, Z Dosztányi, Z Dosztányi   +58 more
core   +3 more sources

Oxide Interface of Gallium‐Based Liquid Metals: Beneficial Bridge or Hidden Risk?

ChemistryEurope, EarlyView.
Discussion on oxide interfaces in gallium‐based liquid metals have concentrated on their properties, behaviors, and related applications. However, the molecular mechanisms underlying effects, as well as the differences between the presence and absence of the oxide layer, have been less thoroughly discussed.
Yi Fan, Shuai Wang, Xu Hou
wiley   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

The PECACE domain: a new family of enzymes with potential peptidoglycan cleavage activity in Gram-positive bacteria

BMC Genomics, 2005
Background The metabolism of bacterial peptidoglycan is a dynamic process, synthases and cleavage enzymes are functionally coordinated. Lytic Transglycosylase enzymes (LT) are part of multienzyme complexes which regulate bacterial division and elongation.
Di Guilmi Anne, Vernet Thierry, Dideberg Otto, Pagliero Estelle   +3 more
doaj   +1 more source

The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis. [PDF]

Int J Mol Sci
Dehydroepiandrosterone (DHEA), a precursor of steroid sex hormones, is synthesized by steroid 17-alpha-hydroxylase/17,20-lyase (CYP17A1) with the participation of microsomal cytochrome b5 (CYB5A) and cytochrome P450 reductase (CPR), followed by sulfation by two cytosolic sulfotransferases, SULT1E1 and SULT2A1, for storage and transport to tissues in ...
Tumilovich A, Yablokov E, Mezentsev Y, Ershov P, Basina V, Gnedenko O, Kaluzhskiy L, Tsybruk T, Grabovec I, Kisel M, Shabunya P, Soloveva N, Vavilov N, Gilep A, Ivanov A.   +14 more
europepmc   +3 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source