Results 91 to 100 of about 3,761,028 (302)

Sequence of a complete chicken BG haplotype shows dynamic expansion and contraction of two gene lineages with particular expression patterns.

PLoS Genetics, 2014
Many genes important in immunity are found as multigene families. The butyrophilin genes are members of the B7 family, playing diverse roles in co-regulation and perhaps in antigen presentation.
Jan Salomonsen, John A Chattaway, Andrew C Y Chan, Aimée Parker, Samuel Huguet, Denise A Marston, Sally L Rogers, Zhiguang Wu, Adrian L Smith, Karen Staines, Colin Butter, Patricia Riegert, Olli Vainio, Line Nielsen, Bernd Kaspers, Darren K Griffin, Fengtang Yang, Rima Zoorob, Francois Guillemot, Charles Auffray, Stephan Beck, Karsten Skjødt, Jim Kaufman   +22 more
doaj   +1 more source

In silico and biochemical analysis of Physcomitrella patens photosynthetic antenna: identification of subunits which evolved upon land adaptation. [PDF]

PLoS ONE, 2008
BackgroundIn eukaryotes the photosynthetic antenna system is composed of subunits encoded by the light harvesting complex (Lhc) multigene family.
Alessandro Alboresi, Stefano Caffarri, Fabien Nogue, Roberto Bassi, Tomas Morosinotto   +4 more
doaj   +1 more source

A phylogenetic approach disentangles interlocus gene conversion tract length and initiation rate [PDF]

arXiv, 2019
Interlocus gene conversion (IGC) homogenizes paralogs. Little is known regarding the mutation events that cause IGC and even less is known about the IGC mutations that experience fixation. To disentangle the rates of fixed IGC mutations from the tract lengths of these fixed mutations, we employ a composite likelihood procedure.
arxiv  

Evolution of a multigene family of chorion proteins in silkmoths. [PDF]

Molecular and Cellular Biology, 1982
The evolution of the A family of chorion genes was examined by comparing new protein and DNA sequences from the silkmoths Antheraea pernyi and Bombyx mori with previously known sequences from Antheraea polyphemus. The comparisons indicated that the A family and its major subfamilies are ancient and revealed how parts of the genes corresponding to ...
Fotis C. Kafatos, George C. Rodakis, Nicholas K. Moschonas   +2 more
openaire   +3 more sources

The Time Lag Associated With the Reclassification of Germline BRCA Variants' Pathogenicity Is Critical for Cancer Patients

Cancer Science, EarlyView.
The period for reclassifying the variants' pathogenicity is too long for patients with advanced or recurrent cancers with variants of uncertain significance that can be objectively re‐evaluated to be (likely) pathogenic according to accumulated evidence.
Tomomi Hayashi, Hiroyuki Matsubayashi, Yoshimi Kiyozumi   +2 more
wiley   +1 more source

A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer

JAMA Oncology, 2019
Key Points Question Is unselected genetic testing of all women with breast cancer cost-effective compared with testing based on clinical criteria or family history?
Li Sun, Li Sun, A. Brentnall, Shreeya Patel, Shreeya Patel, D. Buist, E. Bowles, D. Evans, D. Eccles, J. Hopper, Shuai Li, M. Southey, M. Southey, M. Southey, S. Duffy, J. Cuzick, I. D. S. Silva, A. Miners, Z. Sadique, Li Yang, R. Legood, R. Manchanda   +21 more
semanticscholar   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

Cancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao, Naiquan Mao, Shangping Xing, Zhiquan Chen, Zhuo Luo, Jie Yang   +14 more
wiley   +1 more source

Differences in expression of the RBCS multigene family and rubisco protein content in various rice plant tissues at different growth stages.

Plant and Cell Physiology, 2009
Four out of five members of the RBCS multigene family (OsRBCS2-OsRBCS5) were highly expressed in leaf blades of rice (Oryza sativa L.) irrespective of plant growth stage, whereas accumulation of all RBCS mRNAs in leaf sheaths, roots and developing ...
Yuji Suzuki, K. Nakabayashi, Ryuichi Yoshizawa, T. Mae, A. Makino   +4 more
semanticscholar   +1 more source

Diversity of U1 Small Nuclear RNAs and Diagnostic Methods for Their Mutations

Cancer Science, EarlyView.
Complex interindividual U1 snRNA diversity was unveiled. Mutations in such complex loci were precisely detected with a pangenome graph reference, which enhances the possibility of the human pangenome reference in cancer genomics. ABSTRACT U1 small nuclear RNA (snRNA) mutations are recurrent non‐coding alterations found in various malignancies, yet ...
Takuma Nakashima, Tsubasa Miyauchi, Ryota Takeuchi, Yuriko Sugihara, Yusuke Funakoshi, Fumiharu Ohka, Sachi Maeda, Junko Hirato, Takako Yoshioka, Hajime Okita, Yoshitaka Narita, Yonehiro Kanemura, Yasuhiro Kojima, Yuko Watanabe, Ryuta Saito, Hiromichi Suzuki   +15 more
wiley   +1 more source

Plasmodium falciparum CLAG Paralogs All Traffic to the Host Membrane but Knockouts Have Distinct Phenotypes

Microorganisms
Malaria parasites increase their host erythrocyte’s permeability to obtain essential nutrients from plasma and facilitate intracellular growth. In the human Plasmodium falciparum pathogen, this increase is mediated by the plasmodial surface anion channel
Ankit Gupta, Zabdi Gonzalez-Chavez, Sanjay A. Desai   +2 more
doaj   +1 more source