Breast Cancer Research, 2022 Background Multigene panel tests for breast cancer predisposition routinely include ATM as it is now a well-established breast cancer predisposition gene.
Anne-Laure Renault +8 more
doaj +1 more source
Expansive evolution of the TREHALOSE-6-PHOSPHATE PHOSPHATASE gene family in Arabidopsis [PDF]
, 2012 Trehalose is a nonreducing sugar used as a reserve carbohydrate and stress protectant in a variety of organisms. While higher plants typically do not accumulate high levels of trehalose, they encode large families of putative trehalose biosynthesis genes.
Avonce, Nelson +10 more
core +2 more sources
Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily
Microorganisms, 2022 Vivax malaria, caused by Plasmodium vivax, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to Plasmodium falciparum, P.
Youn-Kyoung Goo
doaj +1 more source
Characterization and Antifungal Properties of Wheat Nonspecific Lipid Transfer Proteins
Molecular Plant-Microbe Interactions, 2008 This study simultaneously considered the phylogeny, fatty acid binding ability, and fungal toxicity of a large number of monocot nonspecific lipid transfer proteins (ns-LTP). Nine novel full-length wheat ns-LTP1 clones, all possessing coding sequences of
Jin-Yue Sun +5 more
doaj +1 more source
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction [PDF]
, 2014 Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell
Allred, David R. +30 more
core +5 more sources
Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]
, 2012 The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia +32 more
core +1 more source
Changes in multi-gene cancer panels for children: A 4-year retrospective review. [PDF]
J Genet CounsAbstract The multi‐gene panel is the most utilized genetic test to evaluate for germline cancer predisposition syndromes. However, the rate of change of commercial multigene panels is not well understood, and its value as a standalone test has also not been investigated.
Williams EG +4 more
europepmc +2 more sources
Multigene family isoform profiling from blood cell lineages
BMC Genomics, 2002 Background Analysis of cell-selective gene expression for families of proteins of therapeutic interest is crucial when deducing the influence of genes upon complex traits and disease susceptibility.
Bradding Peter +2 more
doaj +1 more source
Phase and antigenic variation in mycoplasmas [PDF]
, 2010 With their reduced genome bound by a single membrane, bacteria of the Mycoplasma species represent some of the simplest autonomous life forms. Yet, these minute prokaryotes are able to establish persistent infection in a wide range of hosts, even in the ...
Baranowski, Eric +2 more
core +2 more sources
Evolution of genes and repeats in the Nimrod superfamily [PDF]
, 2008 The recently identified Nimrod superfamily is characterized by the presence of a special type of EGF repeat, the NIM repeat, located right after a typical CCXGY/W amino acid motif.
Andrade +51 more
core +1 more source