Results 61 to 70 of about 3,478,892 (251)

Journal of the Malta College of Family Doctors : volume 5 : issue 3 [PDF]

, 2016
MALLIA, P. - Graduation, specialisation and future initiatives -- GRECH, A., AXIAK, S., & GERADA, C. - The interphase between family medicine and mental health -- PULLICINO, G., PAVIA, J., ZINTILIS, S., FRANCALANZA, S., SCIORTINO, P., & SCIORTINO, P. -
Mallia, Pierre, Malta College of Family Doctors   +1 more
core  

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

Genome-Wide Analysis of the Class III Peroxidase Gene Family in Physcomitrium patens and a Search for Clues to Ancient Class III Peroxidase Functions

International Journal of Plant Biology
Plant class III peroxidases (PRXs) catalyze generation of reactive oxygen species and oxidation of various compounds including lignin precursors. PRXs function in cell wall metabolism, defense, and stress responses. However, gene redundancy and catalytic
Vincent P. M. Aparato, Fazle Rabbi, Taylor Madarash, Wyllie A. Brisbourne, Elizabeth I. Barker, Dae-Yeon Suh   +5 more
doaj   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, EarlyView.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions [PDF]

, 2008
The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase, lactoperoxidase, and thyroid peroxidase.
Ó Fágáin, Ciarán, O'Connor, B, Noeleen B Loughran, Mary J O'Connell, O\u27Connor, Brendan, O'Connell, MJ, O\u27Connell, Mary J., Brendan O'Connor, O'Connor, Brendan, Loughran, Noeleen B., Ciaran O'Fagain, O'Connell, Mary J., Loughran, NB, Ó'Fágáin, C, Loughran Noeleen B, O'Connell Mary J, Ó'Fágáin Ciarán, O'Connor Brendan   +17 more
core   +2 more sources

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

A wheat gene TaSAP17-D encoding an AN1/AN1 zinc finger protein improves salt stress tolerance in transgenic Arabidopsis

Journal of Integrative Agriculture, 2018
The stress-associated protein (SAP) multigene family is conserved in both animals and plants. Its function in some animals and plants are known, but it is yet to be deciphered in wheat (Triticum aestivum L.).
Qiao-fang XU, Xin-guo MAO, Yi-xue WANG, Jing-yi WANG, Ya-jun XI, Rui-lian JING   +5 more
doaj   +1 more source

The Coalescent and Infinite-Site Model of a Small Multigene Family [PDF]

, 2003
The infinite-site model of a small multigene family with two duplicated genes is studied. The expectations of the amounts of nucleotide variation within and between two genes and linkage disequilibrium are obtained, and a coalescent-based method for ...
印南, 秀樹, INNAN, Hideki
core  

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

Insights into Divergent Leishmaniasis Pathogenesis: A Quantitative Flagellar Proteomic Comparison of L. mexicana, L. amazonensis, and L. infantum

Microorganisms
Leishmaniasis, a neglected tropical disease endemic to 98 countries, affects more than 300 million people worldwide. The disease is transmitted through the bite of infected female phlebotomine sand flies harboring Leishmania parasites. Although infection
Diya Lalu Patel, Seok-Young Kim, Olga Uchakina, Niani Angelle Clermont, Jean Byung Hyun, Aleem Damji Patni, Manas Paresh Patel, Shan Khan, Dhruv K. Rana, Chan Hyun Na, Sung-Jae Cha   +10 more
doaj   +1 more source