Cryptic MHC Polymorphism Revealed but Not Explained by Selection on the Class IIB Peptide-Binding Region [PDF]
, 2012 The immune genes of the major histocompatibility complex (MHC) are characterized by extraordinarily high levels of nucleotide and haplotype diversity. This variation is maintained by pathogen-mediated balancing selection that is operating on the peptide ...
Barcaccia +32 more
core +1 more source
Breast Cancer Research, 2022 Background Multigene panel tests for breast cancer predisposition routinely include ATM as it is now a well-established breast cancer predisposition gene.
Anne-Laure Renault +8 more
doaj +1 more source
The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction [PDF]
, 2014 Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell
Allred, David R. +30 more
core +6 more sources
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli [PDF]
, 2014 Background: Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans and other wild and domestic mammals across Central and South America.
A Buschiazzo +172 more
core +3 more sources
Characterization and Antifungal Properties of Wheat Nonspecific Lipid Transfer Proteins
Molecular Plant-Microbe Interactions, 2008 This study simultaneously considered the phylogeny, fatty acid binding ability, and fungal toxicity of a large number of monocot nonspecific lipid transfer proteins (ns-LTP). Nine novel full-length wheat ns-LTP1 clones, all possessing coding sequences of
Jin-Yue Sun +5 more
doaj +1 more source
The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomes [PDF]
, 2012 Patterns of genetic diversity in parasite antigen gene families hold important information about their potential to generate antigenic variation within and between hosts.
Awadalla +12 more
core +1 more source
Evolution of genes and repeats in the Nimrod superfamily [PDF]
, 2008 The recently identified Nimrod superfamily is characterized by the presence of a special type of EGF repeat, the NIM repeat, located right after a typical CCXGY/W amino acid motif.
Andrade +51 more
core +1 more source
Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily
Microorganisms, 2022 Vivax malaria, caused by Plasmodium vivax, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to Plasmodium falciparum, P.
Youn-Kyoung Goo
doaj +1 more source
Resurrection and emendation of the Hypoxylaceae, recognised from a multigene phylogeny of the Xylariales [PDF]
, 2017 A multigene phylogeny was constructed, including a significant number of representative species of the main lineages in the Xylariaceae and four DNA loci the internal transcribed spacer region (ITS), the large subunit (LSU) of the nuclear rDNA, the ...
Heitkämper, Simone +10 more
core +2 more sources
Study on differential expression of 1-aminocyclopropane-1-carboxylic acid oxidase genes in table grape cv. Thompson Seedless [PDF]
, 2013 As a consequence of the non-climacteric status of grapes (Vitis vinifera), ethylene biosynthesis and signal transduction have scarcely been studied in this fruit.
Campos-Vargas, Reinaldo +5 more
core +3 more sources