Results 61 to 70 of about 84,209 (281)

Association between multimorbidity patterns and disability among older people covered by long-term care insurance in Shanghai, China

BMC Public Health, 2021
Background Functional disability and multimorbidity are common among older people. However, little is known about the relationship between functional disability and different multimorbidity combinations.
Zijing Wang, Wenjia Peng, Mengying Li, Xinghui Li, Tingting Yang, Cancan Li, Huosheng Yan, Xianjie Jia, Zhi Hu, Ying Wang   +9 more
doaj   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

The prevalence of multimorbidity and associations with lifestyle factors among middle-aged Canadians: an analysis of Canadian Longitudinal Study on Aging data

BMC Public Health, 2019
Background Multimorbidity can be defined as the presence of more than one chronic condition in an individual. Research on multimorbidity has predominantly focused on older adults and few studies have examined multimorbidity in middle-aged people.
Mohammad Nazmus Sakib, Shahin Shooshtari, Philip St. John, Verena Menec   +3 more
doaj   +1 more source

A hypothesis - generating Swedish extended national cross-sectional family study of multimorbidity severity and venous thromboembolism

BMJ Open, 2023
Objectives Venous thromboembolism (VTE) is a common worldwide disease. The burden of multimorbidity, that is, two or more chronic diseases, has increased. Whether multimorbidity is associated with VTE risk remains to be studied.
Anders Halling, Kristina Sundquist, Jan Sundquist, Bengt Zöller, MirNabi Pirouzifard, Jonatan Ahrén, Björn Holmquist   +6 more
doaj   +1 more source

A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster

Animal Models and Experimental Medicine, EarlyView.
This study presents the first comprehensive proteome and phosphoproteome atlas of the Chinese hamster across nine organs (heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary). A total of 14 219 proteins were identified in the proteome, with 11 828 phosphorylated proteins and 47 122 phosphorylation sites ...
Luyao Zhang, Tao Ding, Wanjun Peng, Jie Kong, Xiaoyue Tang, Jiyu Xu, Qiaochu Wang, Zhiyi Zhang, Chunmei Shi, Yizhuo Tian, Huilan Yang, Yehong Yang, Yue Wu, Xiaoyan Liu, Jiangfeng Liu, Juntao Yang   +15 more
wiley   +1 more source

Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer

Nature Communications
Post-operative recurrence rates of stage I non-small cell lung cancer (NSCLC) range from 20% to 40%. Nonetheless, the molecular mechanisms underlying recurrence hitherto remain largely elusive.
Chengdi Wang, Jingwei Li, Jingyao Chen, Zhoufeng Wang, Guonian Zhu, Lujia Song, Jiayang Wu, Changshu Li, Rong Qiu, Xuelan Chen, Li Zhang, Weimin Li   +11 more
doaj   +1 more source

Shared decision-making about cardiovascular disease medication in older people: A qualitative study of patient experiences in general practice [PDF]

, 2019
Objectives To explore older people's perspectives and experiences with shared decision-making (SDM) about medication for cardiovascular disease (CVD) prevention.
Bonner, Carissa, Doust, Jenny, Jansen, Jesse, McCaffery, Kirsten, McKinn, Shannon, Muscat, Danielle Marie   +5 more
core   +2 more sources

Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Plasma biomarkers of Alzheimer's disease (AD) pathology are frequently tested in specialized research settings, which limits the generalizability of findings. Using electronic health records and banked plasma, we evaluated plasma biomarkers—phosphorylated tau 217 (p‐tau217), β‐amyloid 1–42/1–40 (Aβ42/Aβ40) and p‐tau217/Aβ42—in a real‐world ...
Katheryn A.Q. Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A. Brown, Kyra S. O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T. McMillan, Edward B. Lee, Leslie M. Shaw, David A. Wolk   +12 more
wiley   +1 more source

Multimorbidity: Technical Series on Safer Primary Care [PDF]

, 2016
No abstract ...
Fischbacher-Smith, Denis, Furler, John, Mercer, Stewart, Moffat, Keith, Sanci, Lena   +4 more
core  

The German MultiCare-study : patterns of multimorbidity in primary health care - protocol of a prospective cohort study [PDF]

, 2009
Background Multimorbidity is a highly frequent condition in older people, but well designed longitudinal studies on the impact of multimorbidity on patients and the health care system have been remarkably scarce in numbers until today.
Ingmar Schäfer, Heike Hansen, Gerhard Schön, Wolfgang Maier, Susanne Höfels, Attila Altiner, Angela Fuchs, Ferdinand M Gerlach, Juliana J Petersen, Jochen Gensichen, Sven Schulz, Steffi Riedel-Heller, Melanie Luppa, Siegfried Weyerer, Jochen Werle, Horst Bickel, Kerstin Barth, Hans-Helmut König, Anja Rudolph, Birgitt Wiese, Jana Prokein, Monika Bullinger, Olaf von dem Knesebeck, Marion Eisele, Hanna Kaduszkiewicz, Karl Wegscheider, Hendrik van den Bussche, M Van den Akker, A Marengoni, M Fortin, R Gijsen, A Hessel, J Nuyen, MI Bisschop, CM Boyd, M Fortin, T Luck, B Terluin, JI Sheikh, JC Morris, TL Lash, F Buntinx, MD Miller, M Von Korff, S Heinrich, J Gensichen, FE Harrell, JD Singer, C Collin, MP Lawton, K Bös, K Welsh, W Van der Elst, BW Klasen, EuroQol Group, CL Craig, K Bush, A Hinz, T Fydrich, T Rosemann, L Schenk, H Brauns   +61 more
core   +1 more source