Results 71 to 80 of about 84,209 (281)

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Prevalence of disability according to multimorbidity and disease clustering: a population-based study [PDF]

, 2011
Background: The prevalence of chronic diseases has increased with population ageing, and research has attempted to elucidate the correlation between chronic diseases and disability. However, most studies in older populations have focused on the effect of
Angleman, Sara, Fratiglioni, Laura, Marengoni, Alessandra   +2 more
core   +1 more source

Multimorbidity in bipolar disorder and under-treatment of cardiovascular disease: a cross sectional study [PDF]

, 2013
Background: Individuals with serious mental disorders experience poor physical health, especially increased rates of cardiometabolic morbidity and premature morbidity.
A Weeke, AJ Ferrari, AJ Mitchell, B Felker, B Ya-Mei, Bruce Guthrie, C Astrup, C Crump, CW Colton, Daniel J Smith, Daniel Martin, DJ Smith, E Koranyi, EH Høyer, F Angst, FG Joseph, Gary McLean, J Johnson, J Langan, JA Mackell, Julie Langan, K Barnett, LM Koran, M De Hert, M De Hert, M De Hert, M Tohen, MJ Fleury, MT Tsuang, N Myles, O Bratfos, P Vestergaard, PA Kurdyak, R Sharma, RM Weinryb, SH Han, Stewart W Mercer, T Callréus, TM Laursen, TM Laursen, U Osby, U Petterson, VMR Carstairs   +42 more
core   +3 more sources

Prescribing of Medication to Prevent Glucocorticoid Harms in Patients With Polymyalgia Rheumatica: A Cross‐Sectional Study and Two Emulated Target Trials in the Clinical Practice Research Datalink Aurum

Arthritis &Rheumatology, EarlyView.
Objective Polymyalgia rheumatica (PMR) is a common indication for long‐term glucocorticoid (GC) treatment. Bone‐protective and gastroprotective medications are recommended for those at high risk of adverse events from GCs, but no trials have evaluated their effectiveness in PMR.
Helen Twohig, David Jenkinson, James Bailey, Samantha Hider, Ian C. Scott, Sara Muller   +5 more
wiley   +1 more source

Social determinants of multimorbidity and multiple functional limitations among the ageing population of England, 2002–2015

SSM: Population Health, 2019
This study explores longitudinal relationships between material, psycho-social and behavioural social determinants of health and multimorbidity of people aged 50 years or older in England.
Leo Singer, Mark Green, Francisco Rowe, Yoav Ben-Shlomo, Karyn Morrissey   +4 more
doaj   +1 more source

Influences of Body Composition, Multimorbidity and Polypharmacy on Physical Mobility of Older Adults

, 2016
Background and Purpose: The prevalence of falls, and the resulting injuries and complications reflect a key concern in the older adult population. An increased risk of falls is highly correlated with decreases in physical mobility and related functions ...
Chen, Chieh, Sestini, Linna, Wilde, Rachel   +2 more
core   +1 more source

Clinical pharmacology consultations and their implementation in clinical decision making

British Journal of Clinical Pharmacology, EarlyView.
Aims One of the key roles of clinical pharmacologists is to work as consultants for other medical specialties. We wanted to investigate the characteristics of clinical pharmacology consultations, compare the types of consultations from different specialties, and evaluate how well the recommendations given were followed.
Mirjam Kauppila, Janne T. Backman, Outi Lapatto‐Reiniluoto   +2 more
wiley   +1 more source

The association between multiple long‐term conditions and dementia: A UK cohort study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Studies examining the risk of dementia in people with multimorbidity are commonly conducted in research cohorts or outside the UK. Multimorbidity has historically been associated with aging, but recent research suggests that more than half ...
Hilary Shepherd, Adam Todd, David R. Sinclair, Charlotte L. Richardson, Fiona E. Matthews, Andrew Kingston   +5 more
doaj   +1 more source

The association between lower urinary tract symptoms and falls: forming a theoretical model for a research agenda [PDF]

, 2017
Background: There is a well-recognised association between falls and lower urinary tract symptoms (LUTS) in older adults, with estimates of odd ratios for falls in the presence of LUTS ranging between 1.5 and 2.3. Falls and LUTS are both highly prevalent
Booth, Joanne, Camicioli, Richard, Dumoulin, Chantale, Gibson, William, Hunter, Kathleen F., Paul, Lorna, Skelton, Dawn A., Wagg, Adrian   +7 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source