Results 91 to 100 of about 21,339 (261)

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

open access: yesAdvanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler   +4 more
wiley   +1 more source

Multiphoton imaging in conjunction with ICG imaging by a rigid endomicroscope combined with laser ablation in the head and neck region

open access: yes, 2023
Here, we present a new handheld multiphoton endomicroscopic system designed for tumor diagnosis in the head and neck region. It consists of an approx.
Lai, Chenting   +26 more
core   +1 more source

Neuronal imaging with ultrahigh dynamic range multiphoton microscopy

open access: yesScientific Reports, 2017
Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength.
Ruohui Yang   +4 more
doaj   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

open access: yesAdvanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu   +7 more
wiley   +1 more source

Potential solutions for confocal imaging of living animals

open access: yesBioTechniques, 2007
The use of confocal and multiphoton microscopy for in vivo studies in animals continues to be an area of exciting technical and commercial development. However, the application of these technologies at high resolution, such that molecular and subcellular
Claudette St. Croix   +2 more
doaj   +1 more source

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

open access: yesAdvanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang   +15 more
wiley   +1 more source

Multiphoton Fluorescence and Second Harmonic Generation Microscopy for Imaging Infectious Keratitis

open access: yes, 2008
The purpose of this study is to demonstrate the application of multiphoton fluorescence and second harmonic generation ( SHG) microscopy for the ex-vivo visualization of human corneal morphological alterations due to infectious processes.
TAN, HSIN-YUAN;SUN, YEN;LO, WEN;TENG, SHU-WEN;JEE SHIOU-HWA;LIN, WEI-CHOU;HSIAO, CHING-HSI;LIN, HSIN-CHIUNG;CHEN, YEONG-FONG;MA, DAVID HUI-KANG;HUANG, SAMUEL CHAO-MING;DONG, CHEN-YUAN;LIN, SUNG-JAN   +1 more
core  

Two-photon microscopy : sequential imaging studies in vivo [PDF]

open access: yes, 2011
Microscopists have always desired to look inside various organ tissues to study structure, function and dysfunction of their cellular constituents. In the past, this has frequently required tissue extraction and histological preparation to gain access ...
Zammit, Christian   +4 more
core  

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

open access: yesAdvanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu   +5 more
wiley   +1 more source

The effects of spherical aberration on multiphoton fluorescence excitation microscopy

open access: yes, 2011
Multiphoton fluorescence excitation microscopy is almost invariably conducted with samples whose refractive index differ from that of the objective immersion medium, conditions that cause spherical aberration.
Byars, J. M.   +4 more
core   +1 more source

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