Results 131 to 140 of about 21,339 (261)

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Confocal microscopy

, 2011
Chapter focusing on confocal microscopy. A confocal microscope is one in which the illumination is confined to a small volume in the specimen, the detection is confined to the same volume and the image is built up by scanning this volume over the ...
Wilson, Tony, McConnell, Gail, Amos, William   +2 more
core  

Adaptive optics multiphoton microscopy to study ex vivo ocular tissues

, 2010
We develop an adaptive optics (AO) multiphoton microscope by incorporating a deformable mirror and a Hartmann-Shack wavefront sensor. The AO module operating in closed-loop is used to correct for the aberrations of the illumination laser beam.
Artal Soriano, Pablo, Bueno García, Juan Manuel, Pablo Artal, Gualda Manzano, Emilio José, Juan M. Bueno, Emilio J. Gualda   +5 more
core   +1 more source

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

Quantum State‐Resolved Photodissociation Dynamics Study of Transition‐Metal Carbonyl and Nitrosyl

The Chemical Record, EarlyView.
State‐resolved scattering measurements provide experimental visualization of nuclear motions in reacting molecules. Carbonyls and nitrosyls are typical ligands in most of the transition‐metal complexes, which undergo dissociation upon visible and ultraviolet photoexcitation.
Keigo Nagamori, Hiroyuki Nakata, Hiroshi Kohguchi   +2 more
wiley   +1 more source

Improving multiphoton microscopy using annular beam shaping, focusing on imaging of human skin

, 2014
Multiphoton fluorescence microscopy (MPM) is a method for high resolution, non-invasive investigations of biological tissue. The aim of introducing an annular shaped laser beam is to reduce the ouf-of-focus generated background signal improving imaging ...
Borglin, Johan,, Ericson, Marica B,, Ferhanoǧlu, O., Guldbrand, Stina,, Wennberg, Ann-Marie,, Ben-Yakar, A., Durr, N.J., Hanstorp, Dag,   +7 more
core   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Polarisation multiphoton multifocal microscopy

, 2013
We show that a diffraction-limited multifocal array that possesses an identical polarisation state in each focal spot can be generated for multiphoton multifocal ...
Min Gu (305818), Han Lin (18925888)
core   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Assessing the reproducibility of a bioimage analysis workflow characterising tissue flow in Drosophila

Journal of Microscopy, EarlyView.
Abstract Reproducibility challenges in bioimage analysis are common. The proliferation of tools and workflows creates a complex ecosystem that is difficult to reproduce without deliberate, explicit reporting and support. We assess the reproducibility of Gehrels et al.(2023) as a representative bioimage analysis workflow.
Mélodie Ambroset, Cesar Augusto Valades‐Cruz, Libert Brice Tonfack, Rocco D'Antuono, Caterina Fuster‐Barceló   +4 more
wiley   +1 more source