Results 181 to 190 of about 21,339 (261)

Intravital Multiphoton Microscopy of Hepatic Metabolism

, 2007
多光子顯微術為1990年代初期發展出來的非線性光學技術。多光子顯微術包含多光子螢光與倍頻訊號，其光切片效果及低侵入性，使這項技術非常適合運用於活體觀察。活體與即時的肝臟影像對於了解肝臟的動態過程非常重要。在此我們發展出獨特的肝臟視窗裝置以及手術技巧，以利用多光子顯微術來研究肝臟的動態過程。藉由觀察6-CFDA在肝細胞內被轉換並經由微膽管排出，我們真正看到肝臟的代謝功能。我們並以肝臟的代謝功能為指標，來衡量由膽管結紮所造成膽汁鬱滯的肝功能。相較於正常肝，膽管結紮1天與2天後的肝臟分泌速率較慢。本實驗中 ...
Liu, Yuan, 劉源
core  

Label-free hyperspectral multiphoton microscopy. [PDF]

Opt Lett
De la Cadena A, Renteria CA, Aksamitiene E, Boppart SA.   +3 more
europepmc   +1 more source

Multiphoton microscopy for label-free multicolor imaging of peripheral nerve. [PDF]

J Biomed Opt, 2022
Rishøj L, Hernández IC, Ramachandran S, Jowett N.   +3 more
europepmc   +1 more source

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens. [PDF]

NPJ Digit Med
Yang Y, Xiao C, Zou D, Wang L, Yang R, Zhang Y, Zhang L, Zhao Z, Qiu S, Liu S, Bai Y, Sun WY, He RR, Chen G, Li T, Luo OJ, Jiang W.   +16 more
europepmc   +1 more source

Temporal focusing multiphoton microscopy with cross-modality multi-stage 3D U-Net for fast and clear bioimaging. [PDF]

Biomed Opt Express, 2023
Hu YY, Hsu CW, Tseng YH, Lin CY, Chiang HC, Chiang AS, Chang ST, Chen SJ.   +7 more
europepmc   +1 more source

Multifiber Array‐Based Photometry System for Multiregional Functional Mapping in the Mouse Brain

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Existing fiber photometry approaches suffer from invasiveness and limited scalability. A newly developed multifiber array‐based photometry system allows targeting multiple brain regions with less invasiveness. The system was validated in two jGCaMP8s‐expressing mouse lines by monitoring GABAergic neural population activity across multiple brain regions
Manil Bradai, Mirna Merkler, Gabriela Gil, Rebecca Davie, Shuzo Sakata   +4 more
wiley   +1 more source

Comparative Analysis of Reflectance Confocal Microscopy and Multiphoton Microscopy in Basal Cell Carcinoma Diagnosis. [PDF]

J Biophotonics
Zhong W, Long L, Feng Y, Han X, Chen J.
europepmc   +1 more source

Resection-inspired histopathological diagnosis of cerebral cavernous malformations using quantitative multiphoton microscopy. [PDF]

Theranostics, 2022
Wang S, Li Y, Xu Y, Song S, Lin R, Xu S, Huang X, Zheng L, Hu C, Sun X, Huang F, Wang X, Chen J.   +12 more
europepmc   +1 more source

Intravital Monitoring of Psoriasis Treatment Response and Drug Delivery Using Multiphoton Fluorescence Lifetime Imaging

Skin Research and Technology, Volume 32, Issue 6, June 2026.
ABSTRACT Background Multiphoton tomography equipped with fluorescence lifetime imaging (MPT‐FLIM) is a novel noninvasive imaging technique for analyzing morphological and metabolic states of skin diseases at a subcellular resolution. The present study is the first to establish MPT‐FLIM as an imaging modality to monitor treatment response in psoriasis ...
Lynhda Nguyen, Christian Mess, Katharina Herberger, Stefan W. Schneider, Volker Huck   +4 more
wiley   +1 more source