Results 211 to 220 of about 843,571 (261)

Antibodies in the study of multiple drug resistance

Cytotechnology, 1993
Multidrug resistance (MDR) is a major problem in cancer chemotherapy. As P-glycoprotein is the key molecule in MDR, many investigators have constructed anti-P-glycoprotein monoclonal antibodies (MAbs). Those antibodies, including MRK16 and C219, were used for elucidation of the mechanism of MDR and for overcoming of MDR.
Y, Heike, T, Tsuruo
openaire   +2 more sources

Drug resistance and drug development in multiple myeloma

Seminars in Oncology, 2002
Circumvention of drug resistance in multiple myeloma is a major obstacle to improving clinical outcomes for myeloma patients. Identification of several mechanisms of acquired drug resistance has led to the development of chemosensitizing agents that counter specific drug resistance mechanisms.
openaire   +2 more sources

Multiple or pleiotropic drug resistance in yeast

Biochimica et Biophysica Acta (BBA) - General Subjects, 1991
The purpose of this review is to gather genetic and biochemical data established on multiple drug resistance in yeast, with a view to the implications that these findings may have for unravelling the mechanism of multidrug resistance in higher ...
E, Balzi, A, Goffeau
openaire   +2 more sources

Multiple drug resistance in the pathogenic protozoa

Acta Tropica, 1994
Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in drug efflux have been compared ...
Peter Upcroft
exaly   +3 more sources

Drug resistance in multiple myeloma.

Seminars in hematology, 1997
The development of multidrug resistance (MDR) is a major obstacle to improving treatment outcomes in multiple myeloma. Recent studies have indicated that several specific mechanisms of MDR may be involved in clinically refractory multiple myeloma patients, such as expression of P-glycoprotein (P-gp), expression of the lung-resistance protein (LRP) and ...
Sonneveld, Pieter, Lokhorst, HM, Vossebelt, PJM   +2 more
openaire   +2 more sources

Topoisomerase II in multiple drug resistance

Cytotechnology, 1993
Topoisomerase II is a target of alkaloid, anthracycline and related antitumor agents. Two types of multiple drug resistance are associated with these enzymes. In classical (typical) multidrug resistance, inhibitors are actively effluxed from cells by P-glycoprotein.
G A, Hofmann, M R, Mattern
openaire   +2 more sources

In vitro models of multiple drug resistance

1994
The emergence of drug resistance in many ways reflects evolution; those cells capable of surviving exposure to an environmental stress propagate. This is particularly important in cancer, where it has been estimated that 90% of the 500,000 annual cancer fatalities in the United States are influenced by drug resistance [1].
L M, Greenberger, D, Cohen, S B, Horwitz
openaire   +2 more sources

Multiple drug resistance inAerobacter aerogenes

Antonie van Leeuwenhoek, 1967
Multiple drug resistance resulting from continued growth in various drugs in turn followed by serial subculture in the simultaneous presence of all the drugs has been studied. In this way strains ofA. aerogenes resistant, in considerable measure, to 3, 4 and 5 drugs have been obtained.
P G, Bolton, A C, Dean, P J, Rodgers
openaire   +2 more sources

Topoisomerase I in multiple drug resistance

Cytotechnology, 1993
Topoisomerase I is a nuclear enzyme able to catalyse the relaxation of supercoiled DNA by introducing single-stranded breaks in DNA molecule. Its function seems important to prepare DNA for many processes such as recombination, DNA repair and RNA transcription.
openaire   +2 more sources

Transmissible Drug-resistance Factors and Formation of Multiple Resistance

Nature, 1962
IN earlier reports several types of drug (chloramphenicol, Cm; tetracycline, Tc; streptomycin, Sm; sulphanilamide, Da) resistant Escherichia coli and Shigella were described1–3. It was also found that seven types of drug resistance are transmitted by cell-to-cell contact4.
S, MITSUHASHI, K, HARADA
openaire   +2 more sources