Results 41 to 50 of about 578,414 (184)

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

In vitro development of chemotherapy and targeted therapy drug-resistant cancer cell lines: a practical guide with case studies [PDF]

, 2014
The development of a drug-resistant cell line can take from 3 to 18 months. However, little is published on the methodology of this development process. This article will discuss key decisions to be made prior to starting resistant cell line development;
Breen, Laura, Busschots, Steven, Clynes, Martin, Crown, John, Eustace, Alex J., McDermott, Martina, O'Donovan, Norma, Stordal, Britta K.   +7 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

A genomic and evolutionary approach reveals non-genetic drug resistance in malaria [PDF]

, 2014
Background: Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms ...
Broadbent, Kate M, Clish, Clary B, Deik, Amy A, Desai, Michael M, Herman, Jonathan D, Mazitschek, Ralph, Moss, Eli L, Neafsey, Daniel E, Ribacke, Ulf, Rice, Daniel P, Silterra, Jacob, Wirth, Dyann F   +11 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Short Report: Association Between Chloroquine and Amodiaquine Resistance and Allelic Variation in the Plasmodium Falciparum Multiple Drug Resistance 1 Gene and the Chloroquine Resistance Transporter Gene in Isolates from the Upper Nile in Southern Sudan. [PDF]

, 2003
Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in Plasmodium falciparum to both drugs has been selected.
Keus, K, Nzila, A, Ochong, E, van den Broek, I   +3 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Knowledge and Attitude of Students on Antimicrobial Resistance at Debre Markos University, Ethiopia [PDF]

, 2016
Irrational use of medicines is a key reason for the increase and spread of antimicrobial resistance and it is a global concern. It is a fast mounting universal crisis. The main of this study of this study was to assess knowledge, attitude and practice of
Bizuayehu, H. M. (Habtamu), Zelellw, D. A. (Desalegne)   +1 more
core  

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa [PDF]

, 2010
Background. The Beijing genotype of M. tuberculosis is a virulent strain that is disseminating worldwide and has a strong association with drug resistance.
A Aubry, A Dessen, AD Calver, AE DeBarber, AG Tsolaki, AL Delcher, B Lopez, BJ Marais, C Manca, C Manca, CK Mlambo, D Almeida, D Hillemann, D van Soolingen, DD Anh, Elizabeth M Streicher, EM Streicher, F Drobniewski, F Wang, G Middlebrook, GD van der Spuy, GE Pfyffer, GP Morlock, I Mokrousov, I Parwati, I Parwati, J Felsenstein, J Kamerbeek, J Werngren, James C Sacchettini, JR Glynn, JR Glynn, Karen M Dobos, L Tsenova, LE Via, M Ebrahimi-Rad, M Hanekom, M Mphahlele, M Pillay, M Richardson, M Zhang, MB Reed, MH Larsen, MW Borgdorff, Nicolaas C Gey van Pittius, OJ Strauss, OS Toungoussova, P Constant, Paul D Van Helden, PJ Bifani, PJ Bifani, Q Li, R Johnson, R Johnson, R Johnson, R Warren, RM Warren, Robin M Warren, S Gagneux, S Kurtz, S Ramaswamy, S Sreevatsan, S Sreevatsan, S Sreevatsan, S Sreevatsan, SI Durbach, SJ Cheng, T Dos Vultos, T Iwamoto, TC Victor, Thomas C Victor, Thomas R Ioerger, TR Frieden, TR Ioerger, Xiaohua Chen, Y Suzuki, Yicheng Feng, YK Park   +77 more
core   +4 more sources