Results 41 to 50 of about 809,845 (306)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Туберкулез и болезни лёгких, 2015 Lately the main TB epidemiological rates are becoming stable in Buryatia Republic. In 2013-2014 the e¾ciency of use of perchlozon was studied within integral treatment of pulmonary tuberculosis patients with multiple and extensive drug resistance (MDR ...
S. V. Nikolaeva
doaj
Multiple drug resistance in Aeromonas hydrophila isolates of fish [PDF]
Veterinary World, 2010 Fourteen antibacterial agents belonging to 9 different groups of antibiotics viz. aminoglycosides, cephalosporins, nitrofurantoin, fluroquinolones, chloramphenicol, sulphonamides, tetracyclines, penicillin and polymixin were used for in vitro sensitivity
Kaskhedikar, M. and Chhabra, D
doaj
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Antibiotic Resistance of Vibrio cholerae Isolates from Kashan, Iran
International Archives of Health Sciences, 2016 Aims: Cholera is an acute diarrheal disease that can lead to severe dehydration and death. Antibiotic resistance is a big challenge in infective disease like Cholera.
Afzali H.MD, +2 more
doaj
Journal of Clinical and Scientific Research, 2020 Background: Antimicrobial resistance (AMR) is of great concern in recent years as it is posing a global threat. The present study was undertaken to identify the prevalence of common bacterial isolates and their antimicrobial susceptibility patterns and ...
N Ramakrishna +4 more
doaj +1 more source
A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment [PDF]
, 2022 Katarína Chromá +7 more
openalex +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source