Results 71 to 80 of about 2,245,687 (336)

Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma

Clinical Epigenetics, 2017
Multiple myeloma (MM) is a hematological malignancy, which remains incurable because most patients eventually relapse or become refractory to current treatments. Due to heterogeneity within the cancer cell microenvironment, cancer cell populations employ
Mark E Issa, Farnaz Sedigheh Takhsha, C. S. Chirumamilla, Claudina A. Pérez-Novo, W. Vanden Berghe, M. Cuendet   +5 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

Journal of Hematology & Oncology, 2022
Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cancer cells in response to therapy-induced hostile environment are largely unknown. As the central organelle for cellular energy supply,
P. Jin, Jingwen Jiang, Li Zhou, Zhao Huang, E. Nice, Canhua Huang, Li Fu   +6 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

Туберкулез и болезни лёгких, 2015
The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV ...
Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova   +2 more
doaj  

In Vitro Efficacy of Imipenem/Relebactam Against Imipenem Resistant Gram-Negative Strains Isolated from a Tertiary Care Hospital

Pakistan Armed Forces Medical Journal
Objective: To determine in vitro efficacy of Imipenem/Relebactam against multi-drug resistant strains. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Fauji Foundation Hospital (FFH) Rawalpindi, Pakistan
Saima Ishtiaq, Sonia Tahir, Muhammad Waqas Abbas, Haider Ali, Saima Syed, Fatima Kareem   +5 more
doaj   +1 more source

Molar ratios of therapeutic water-soluble phenothiazine⋅water-insoluble phospholipid adducts reveal a Fibonacci correlation and a putative link for structure–activity relationships [PDF]

, 2015
The fact that non-antibiotics can sensitise microorganisms for antibiotic treatment suggests that these molecules have valuable potential to treat multiple drug resistance.
Fey, S. J., Keyzer, Hendrik, Kristiansen, Jette E., Thornton, Barry   +3 more
core   +1 more source

Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance

Clinical & Translational Immunology, 2018
Multiple myeloma (MM) is a haematological malignancy of mature antibody‐secreting plasma cells. Currently, MM is incurable, but advances in drug treatments have increased patient lifespan.
Nicholas Nikesitch, James M. Lee, S. Ling, T. Roberts   +3 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Systematic identification of signaling pathways with potential to confer anticancer drug resistance [PDF]

, 2014
Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant complementary DNAs to identify those that enhanced the survival of cancer cells in the ...
Alley, H. M., Anderson, G. R., Chen, P.-L., Cooper, Z. A., Flaherty, K. T., Jasper, J. S., Kwong, L. N., Martz, C. A., McDonnell, D. P., Ottina, Kathleen, Peraza-Penton, A., Rathmell, J. C., Sabatini, David M., Singleton, K. R., Tetzlaff, M., Wang, Tim, Wardell, S. E., Wargo, J. A., Winter, P. S., Wood, K. C.   +19 more
core   +1 more source