Results 21 to 30 of about 38,029,237 (226)

Prognosis after surgery for multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors: Functionality matters [PDF]

, 2021
Background: Metastasized pancreatic neuroendocrine tumors are the leading cause of death in patients with multiple endocrine neoplasia type 1. Aside from tumor size, prognostic factors of pancreatic neuroendocrine tumors are largely unknown.
Pasternak, Jesse D., Nieveen van Dijkum, Elisabeth J., Zagzag, Jonathan, Brandi, Maria Luisa, Verkooijen, Helena M., Nilubol, Naris, Bartsch, Detlef K., Dejong, Cornelis H.C., de Kleine, Ruben H.J., Manoharan, Jerena, Nell, Sjoerd, Conemans, Elfi B., Giri, Sneha, Perrier, Nancy D., van Beek, Dirk Jan, Kazemier, Geert, Sturgeon, Cord, Bonsing, Bert A., Valk, Gerlof D., Brosens, Lodewijk A., Giusti, Francesca, Brunaud, Laurent, van Eijck, Casper H., van Goor, Harry, Hsiao, Ralph, Vriens, Menno R., Goudet, Pierre, Borel Rinkes, Inne H.M., Santucci, Nicolas   +28 more
core   +9 more sources

Breast cancer in multiple endocrine neoplasia type 1 (MEN1)

Endocrinology, Diabetes & Metabolism Case Reports, 2021
A 38-year-old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.1304delG) through predictive genetic testing, following a diagnosis of familial hyperparathyroidism.
Seong Keat Cheah, Chad Ramese Bisambar, Deborah Pitfield, Olivier Giger, Rogier ten Hoopen, Jose-Ezequiel Martin, Graeme R Clark, Soo-Mi Park, Craig Parkinson, Benjamin G Challis, Ruth T Casey   +10 more
doaj   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Expressions of Cushing’s syndrome in multiple endocrine neoplasia type 1

Frontiers in Endocrinology, 2023
Cushing’s syndrome (CS) resulting from endogenous hypercortisolism can be sporadic or can occur in the context of familial disease because of pituitary or extra-pituitary neuroendocrine tumors.
William F. Simonds
doaj   +1 more source

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. [PDF]

, 1996
It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome.
Rendl, J., Frank-Raue, K., Höppner, W., Haase, R., Mann, K., Deckart, H. F., Ritter, M. M., Frilling, A., Scholz, G. H., Dralle, H., Kirchner, R., Kotzerke, J., Klempa, J., Hampel, R., Raue, F., Seif, F.   +15 more
core   +1 more source

Pituitary tumors in patients with MEN1 syndrome

Clinics, 2012
We briefly review the characteristics of pituitary tumors associated with multiple endocrine neoplasia type 1. Multiple endocrine neoplasia type 1 is an autosomal-dominant disorder most commonly characterized by tumors of the pituitary, parathyroid ...
Luis V. Syro, Bernd W. Scheithauer, Kalman Kovacs, Rodrigo A. Toledo, Francisco J. Londoño, Leon D. Ortiz, Fabio Rotondo, Eva Horvath, Humberto Uribe   +8 more
doaj   +1 more source

Isolated familial pheochromocytoma as a variant of von Hippel-Lindau disease. [PDF]

, 1996
Inherited pheochromocytomas are often part of familial syndromes, especially multiple endocrine neoplasia type 2 (MEN 2), retinal cerebellar hemangioblastomatosis [von Hippel-Lindau (vHL) disease] or neurofibromatosis type 1.
Crossey, P.A., Höppner, W., Engelhardt, D., Maher, E.R., Ritter, M.M., Frilling, A., Mulligan, L., Ponder, B.A.J.   +7 more
core   +1 more source

Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1

Clinics, 2012
Primary hyperparathyroidism associated with multiple endocrine neoplasia type I (hyperparathyroidism/multiple endocrine neoplasia type 1) differs in many aspects from sporadic hyperparathyroidism, which is the most frequently occurring form of ...
Delmar M. Lourenço Jr., Flavia L. Coutinho, Rodrigo A. Toledo, Tatiana Denck Gonçalves, Fabio L. M. Montenegro, Sergio P. A. Toledo   +5 more
doaj   +1 more source

Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation

Clinics, 2012
Multiple endocrine neoplasia type 1 is an inherited endocrine tumor syndrome, predominantly characterized by tumors of the parathyroid glands, gastroenteropancreatic tumors, pituitary adenomas, adrenal adenomas, and neuroendocrine tumors of the thymus ...
Cornelis J. Lips, Koen M. Dreijerink, Jo W. Höppener   +2 more
doaj   +1 more source

Presence of Multiple Endocrine Neoplasia-1 Mutations in Patients with Primary Hyperparathyroidism Detected on Clinical and Sonographical Suspicion: Report of 2 Novel Mutations

, 2023
Objective: This study aims to evaluate the presence of multiple endocrine neoplasia-1 mutations in patients with primary hyperparathyroidism detected on clinical and sonographical suspicion.
Oya Topaloglu, Muhammet Cuneyt Bilginer, Bekir Cakir, ERSOY, REYHAN, Hanife Saat, Bekir Çakır, TOPALOĞLU, OYA, Buşranur Çavdarlı, Cevdet Aydin, Saat, Hanife, Fakı, Sevgül, AYDIN, CEVDET, Sevgul Faki, Cevdet Aydın, Sevgül Fakı, Busranur Cavdarli, BİLGİNER, MUHAMMET CÜNEYT, Çavdarlı, Buşranur, ÇAKIR, BEKİR, Reyhan Ersoy   +19 more
core   +1 more source