Results 71 to 80 of about 23,289 (161)

Impact of RET proto-oncogene analysis on the clinical management of multiple endocrine neoplasia type 2

open access: yesClinics, 2006
Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disease characterized by the presence of medullary thyroid carcinoma, primary hyperparathyroidism, and pheochromocytoma.
Toledo Sergio Pereira de Almeida   +3 more
doaj  

GLP‐1 receptor agonists and serious adverse events: Evidence, uncertainty and clinical implications

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists provide benefits in weight reduction, glycaemic control in Type 2 diabetes, and cardiovascular and renal outcomes. Their widespread use has given rise to concerns regarding rare but potentially serious adverse events.
Peter Ueda
wiley   +1 more source

Tumor carcinóide de estômago tipo 1

open access: yesRevista do Colégio Brasileiro de Cirurgiões
Gastric carcinoid occurs in less than 1% of gastric neoplasias and around 2% of carcinoids tumors. They are classified into three forms: type 1, associated with atrophic gastritis, type 2, associated with multiple endocrine neoplasia 1 and Zollinger ...
Rubens Valarini   +2 more
doaj   +1 more source

Oncocytic variant of medullary thyroid carcinoma: a rare case of sporadic multifocal and bilateral RET wild-type neoplasm with revision of the literature

open access: yesRare Tumors, 2016
Oncocytic variant of medullary thyroid carcinoma (OV-MTC) is a very unusual entity, up to date only 17 cases have been reported in the literature. MTC is a neuro-endocrine malignancy arising from the para-follicular C cells of the thyroid gland.
Gian Luca Rampioni Vinciguerra   +5 more
doaj   +1 more source

Preclinical Target Animal Safety Evaluation of Veterinary Monoclonal Antibodies: Principles, Methods, and Interpretation

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) represent a rapidly expanding pharmaceutical class in veterinary medicine, with several products now authorized for use in dogs and cats. Limited published articles and veterinarian exposure to the principles of drug development present challenges in interpreting published safety evaluations that inform product ...
Adam Werts   +6 more
wiley   +1 more source

Pathologic Characterization and Clinical Significance of Lymphovascular Invasion in Canine Thyroid Carcinomas

open access: yesVeterinary and Comparative Oncology, EarlyView.
ABSTRACT The association between lymphovascular invasion (LVI) and outcomes in dogs with thyroid carcinoma is inadequately described, and a standardized definition of LVI is lacking. This study's objectives were to histopathologically and immunohistochemically characterize LVI and to evaluate associated clinical outcomes in dogs with thyroid carcinoma.
Maureen A. Griffin   +6 more
wiley   +1 more source

Codocytosis in the Dog: 345 Cases (2020–2022)

open access: yesVeterinary Clinical Pathology, EarlyView.
ABSTRACT Introduction Codocytes, or target cells, are a morphologic variation of erythrocytes characterized by increased membrane surface area relative to volume. In dogs, codocytosis is frequently noted on blood smear evaluation, but its clinical significance remains poorly understood. Objectives To characterize the clinical conditions associated with
Sarena M. Krojanker   +5 more
wiley   +1 more source

Efficacy of iodine-131-metaiodobenzylguanidine therapy for multiple endocrine neoplasia type 2A-associated metastatic pheochromocytoma: case report and literature review

open access: yesEndocrine Journal
Malignant transformation in multiple endocrine neoplasia type 2 (MEN2)-associated pheochromocytoma is rare, and there have been few reports of treatment with 131I-metaiodobenzylguanidine (MIBG) therapy.
Kentaro Suda   +12 more
doaj   +1 more source

Persistent Erythrocytosis in a Dog With a Spinal Sclerosing Paraganglioma

open access: yesVeterinary Clinical Pathology, EarlyView.
ABSTRACT A 7‐year‐old, male, castrated, mixed‐breed dog presented with right pelvic limb lameness and pain on posturing to defecate that began 1.5 years prior to presentation. Radiographs taken 8 months prior to presentation showed a small lytic lesion of the L6 vertebral body, and CBCs showed a persistently increased hematocrit (HCT) for at least 2 ...
Samuel V. Neal   +11 more
wiley   +1 more source

Cytologic Characteristics of the Feline Ovary at Different Sexual Stages

open access: yesVeterinary Clinical Pathology, EarlyView.
ABSTRACT Background Cytology is a valuable diagnostic tool in veterinary medicine, allowing rapid and minimally invasive diagnosis. However, its application in the reproductive tracts of small animals is limited, primarily used to assess mammary masses and stage the estrous cycle.
Alba Martí   +4 more
wiley   +1 more source

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