Results 81 to 90 of about 510,364 (266)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Cubic differential systems with an invariant straight line of maximal multiplicity

open access: yes, 2015
In this work the estimation 3n-2 le;Man le; 3n -1 of maximal algebraic multiplicity Man of an invariant straight line is obtained for two-dimensional polynomial diffierential systems of degree n ge;2. In the class of cubic systems n = 3 we have Ma3 = 7: Moreover, we prove that if an affine real invariant straight line has multiplicity equal to 1 ...
Şubă, A.S., Vacaraş, O.V.
openaire   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

The Real and Complex Techniques in Harmonic Analysis from the Point of View of Covariant Transform

open access: yes, 2014
This note reviews complex and real techniques in harmonic analysis. We describe a common source of both approaches rooted in the covariant transform generated by the affine group.
Kisil, Vladimir V.
core  

Inductive Visual Localisation: Factorised Training for Superior Generalisation [PDF]

open access: yes, 2018
End-to-end trained Recurrent Neural Networks (RNNs) have been successfully applied to numerous problems that require processing sequences, such as image captioning, machine translation, and text recognition.
Gupta, Ankush   +2 more
core   +2 more sources

First integrals and phase portraits of planar polynomial differential cubic systems with invariant straight lines of total multiplicity eight

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2017
Summary: In the article [\textit{C. Bujac} et al., Qual. Theory Dyn. Syst. 15, No. 2, 327--348 (2016; Zbl 1367.34030)] for the family of cubic differential systems with the maximum number of invariant straight lines, i.e. 9 (considered with their multiplicities), the all first integrals and phase portraits were constructed.
Cristina Bujac, Nicolae Vulpe
openaire   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

On the family QSL3 of quadratic systems with invariant lines of total multiplicity exactly 3

open access: yes, 2022
Let QSLge;i be the family of quadratic differential systems with invariant lines of total multiplicity at least i and let QSLi denote the family of quadratic systems with invariant lines of total multiplicity exactly i. For any polynomial system the line at infinity is invariant. Thus the family QS of all quadratic systems is the same as QSLge;1.
Bujac, C., Schlomiuk, D.I., Vulpe, N.I.
openaire   +1 more source

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