Results 101 to 110 of about 5,702,542 (372)
Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma.
New England Journal of Medicine, 2015 BACKGROUND Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed ...
A. Keith Stewart +29 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study elucidates the crosstalk between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer stem cells (ATCSCs). The findings reveal that CCL20 from THP‐1‐M2 activates the IRAK‐1/NF‐κB1/2 pathway in ATCSCs, thereby enhancing CXCL5 secretion.
Qi Liu +11 more
wiley +1 more source
Dental management before radiotherapy of the head and neck region: 4‐year single‐center experience
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1478-1486, December 2022., 2022 Abstract Objective To review our experience with a standardized dental management approach in patients with planned radiotherapy of the head and neck region based on preradiation and follow‐up data. Material and Methods Records of patients who underwent radiotherapy between June 2016 and November 2020 were reviewed.
Lea Hoffmann +5 more
wiley +1 more source
Asymmetric Cascade Networks for Focal Bone Lesion Prediction in Multiple Myeloma [PDF]
arXiv, 2019 The reliable and timely stratification of bone lesion evolution risk in smoldering Multiple Myeloma plays an important role in identifying prime markers of the disease's advance and in improving the patients' outcome. In this work we provide an asymmetric cascade network for the longitudinal prediction of future bone lesions for T1 weighted whole body ...
arxiv
Improving drug sensitivity predictions in precision medicine through active expert knowledge elicitation [PDF]
, 2017 Predicting the efficacy of a drug for a given individual, using high-dimensional genomic measurements, is at the core of precision medicine. However, identifying features on which to base the predictions remains a challenge, especially when the sample size is small.
arxiv +1 more source
Advanced Science, EarlyView.The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu +13 more
wiley +1 more source
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
Experimental Hematology & Oncology, 2022 Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including cancer.
Eugenio Morelli +22 more
doaj +1 more source
Towards whole-body CT Bone Segmentation [PDF]
, 2018 Bone segmentation from CT images is a task that has been worked on for decades. It is an important ingredient to several diagnostics or treatment planning approaches and relevant to various diseases. As high-quality manual and semi-automatic bone segmentation is very time-consuming, a reliable and fully automatic approach would be of great interest in ...
arxiv +1 more source
Advanced Science, EarlyView.A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang +16 more
wiley +1 more source
Genomic patterns of progression in smoldering multiple myeloma
Nature Communications, 2018 Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but ...
Niccolò Bolli +23 more
doaj +1 more source