Results 171 to 180 of about 5,752,243 (395)

Maintenance Therapy in the Era of Quadruplets for Multiple Myeloma: When, What, and for How Long?

American Journal of Hematology, EarlyView.
Hira Mian, Luciano J. Costa
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

URETHANE (ETHYL CARBAMATE) THERAPY IN MULTIPLE MYELOMA [PDF]

, 1949
J. PHILIP LOGE, R. Wayne Rundles
openalex   +1 more source

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, EarlyView.
Chromenone derivatives are synthesized and evaluated as inhibitors of chromosome region maintenance 1‐mediated nuclear export, targeting glioblastoma cells. Active compounds demonstrate structure‐ and dose‐dependent inhibition, supported by structure–activity relationships and molecular docking studies.
Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea‐Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira, Wolfgang Link   +10 more
wiley   +1 more source

STUDIES IN SERUM ELECTROLYTES. XV. THE CALCIUM-BINDING PROPERTY OF THE SERUM PROTEINS (MULTIPLE MYELOMA, LYMPHOGRANULOMA VENEREUM AND SARCOIDOSIS) [PDF]

, 1948
Arnold J. Rawson, F. William Sunderman
openalex   +1 more source

Synthesis and 64Cu‐Radiolabeling Strategies of Small Organic Radioconjugates Based on the AMD070 Scaffold

ChemMedChem, EarlyView.
Two novel 64Cu‐radioconjugates have been prepared, based on the AMD070 scaffold as a targeting unit and cyclam‐based te1pa chelator, for future applications in positron emission tomography imaging. Synthesis of ligands and their 64Cu‐radiolabeling are described herein.
Marie M. Le Roy, Patricia Le Saëc, Michel Chérel, Alain Faivre‐Chauvet, Thibault Troadec, Raphaël Tripier   +5 more
wiley   +1 more source

Role of minimal residual disease assessment in multiple myeloma

Haematologica
Multiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of plasma cells. MM is a heterogeneous disease, featured by various molecular subtypes with different outcomes. With the advent of very efficient therapies including
Raphael Szalat, Kenneth Anderson, Nikhil Munshi   +2 more
doaj   +1 more source

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]

, 2020
The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core  

Expert Perspective: Hematologic Malignancies and Vasculitis

Arthritis &Rheumatology, EarlyView.
Michelle L. Robinette, Hetty E. Carraway
wiley   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, EarlyView.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source