Results 71 to 80 of about 80,790 (265)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
FINANCIAL STRUCTURE OPTIMIZATION BY USING A GOAL PROGRAMMING APPROACH
Croatian Operational Research Review, 2012 This paper proposes a new methodology for solving the multiple objective fractional linear programming problems using Taylor’s formula and goal programming techniques.
Tunjo Perić, Zoran Babić
doaj
Multiobjective route finding in a multimode transportation network by NSGA-II
Journal of Engineering and Applied ScienceRoute finding is an everyday challenge for urban residents. While many route planner applications exist, they cannot find suitable routes based on user preferences. According to user preferences, routing in a multimode urban transportation network can be
Hamed Faroqi
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The political districting of Kuwait: Heuristic approaches
Kuwait Journal of Science, 2015 This paper models the political districting of Kuwait as a multiple objective combinatorialoptimization problem, where each political system is assessed in terms of population andvoting equity, geographical contiguity, and social, religious, ethnic ...
SHAFIQAH ALAWADHI, RYM MAHALLA
doaj
Practical common weights scalarizing function approach for efficiency analysis [PDF]
Journal of Optimization in Industrial Engineering, 2010 A characteristic of Data Envelopment Analysis (DEA) is to allow individual decision making units (DMUs) to select the factor weights which are the most advantageous for them in calculating their efficiency scores.
Alireza Alinezhad +3 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source