Results 71 to 80 of about 11,046,276 (309)

Functional clinical outcomes in multiple sclerosis: Current status and future prospects [PDF]

open access: yes, 2015
For decades, the Expanded Disability Status Scale (EDSS) has been the principal measure of disability in clinical trials in patients with multiple sclerosis (MS) and in clinical practice.
Deleu, Dirk T.   +21 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A parameter choice strategy for the inversion of multiple observations [PDF]

open access: yesAdvances in Computational Mathematics, 2016
In many geoscientific applications, multiple noisy observations of different origin need to be combined to improve the reconstruction of a common underlying quantity. This naturally leads to multi-parameter models for which adequate strategies are required to choose a set of 'good' parameters.
Christian Gerhards   +2 more
openaire   +2 more sources

Part mass and shrinkage in micro injection moulding: statistical based optimisation using multiple quality criteria [PDF]

open access: yes, 2013
Purpose: The aim of this paper is to optimise process conditions in micro injection moulding (m-IM) to minimise shrinkage whilst maximising part mass.
Alcock, Jeffrey R.   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Parameters – Full Issue – Spring 2015 [PDF]

open access: yes, 2015
Fighting the “Islamic State”: The Case for US Ground Forces by David E. Johnson Megacities: Pros and Cons by Kevin M. Felix, Frederick D. Wong, Michael Evans, William G. Adamson Culture and the US Army by Matthew Morton, Charles D.
Parameters, USAWC, USAWC Parameters
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Research on Constellation-Splitting Criterion in Multiple Parameters WFRFT Modulations

open access: yesIEEE Access, 2018
We present a novel constellation-splitting criterion in the multiple parameters weighted-type fractional Fourier transform (MP-WFRFT) modulations. First, the signal superposition characteristics are studied and the related four theorems are put forward ...
Yuan Liang   +5 more
doaj   +1 more source

Estimation of Spectral Densities with Multiplicative Parameter

open access: yesActa Applicandae Mathematica, 2003
Let \(\{Y(t)\), \(t\in[0,T]^n\}\) be a stationary random field with zero mean and spectral density \(f(\lambda)=\eta g(\lambda;\theta)\), where \(\eta\) and \(\theta\) are unknown parameters. The authors propose a two-step method for estimating the parameters.
Anh, Vo   +3 more
openaire   +3 more sources

Migration and infectious disease in the etiology of multiple sclerosis: A case-control study

open access: yes, 1989
Epidemiological study on multiple sclerosis risk of migration from South to North ...
Altobelli A.   +2 more
core  

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