Results 91 to 100 of about 12,940,323 (262)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Cancer Trends: Mesothelioma

, 2012
Mesothelioma is a rare cancer of the thin lining that mainly covers the lungs and abdominal cavity. An average of 24 cases of mesothelioma was diagnosed per year in Ireland between 1994 and 2010 (Table 1), representing less than 0.2% of all invasive ...
National Cancer Registry Ireland (NCRI)
core  

Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer [PDF]

, 2013
<p>Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)–extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (CaP). The mechanism
Kalna, G., Yang, Z H, Z H Yang, Leung, H.Y., Scardino, P, L B Singh, Singh, LB, H Møller, C Cooper, Cuzick, J, J Fleming, Singh, L.B., Yang, Z.H., I Ahmad, G Kalna, D M Berney, Singh, L. B., Scardino, P., Leung, H Y, Ahmad, I., Møller, H; id_orcid, J Cuzick, Berney, D. M., Cuzick, J., Møller, H., Leung, H. Y., Berney, DM, Fisher, G., Fleming, J., Cooper, C., Leung, HY, Kalna, G, P Scardino, Yang, Z. H., Berney, D.M., Fisher, G, Cooper, C, Møller, H, Ahmad, I, G Fisher, Yang, ZH, Singh, L B, Fleming, J, H Y Leung, Berney, D M   +44 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Cancer Trends: Soft Tissue Sarcomas [PDF]

, 2014
Sarcomas are a group of uncommon cancers that originate from mesenchymal cells as opposed to more well-known cancers that develop from epithelial tissue.
National Cancer Registry Ireland (NCRI)
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Cancer Trends: Cancer of the pancreas

, 2012
Cancer of the pancreas accounts for approximately 2.5% of all invasive cancers and is the 9th most commonly diagnosed cancer in Ireland.1 Almost 400 cases of pancreatic cancer were diagnosed annually between 1994 and 2010 (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Association between patient and general practice characteristics and unplanned first-time admissions for cancer: observational study. [PDF]

, 2012
BACKGROUND: To identify patient and general practice (GP) characteristics associated with emergency (unplanned) first admissions for cancer in secondary care. METHODS: Patients who had a first-time admission with a primary diagnosis of cancer during 2007/
Bottle, A., A Bottle, M Soljak, C Parsons, Tsang, C, Aylin, P, Soljak, M, Majeed, A., Bottle, A, C Tsang, A Majeed, Parsons, C, Majeed, A, P Aylin, Bottle, Alex, Soljak, M., Aylin, P., Tsang, C., Aylin, Paul, Parsons, C.   +19 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source