Results 71 to 80 of about 12,940,323 (262)

HER3 Is an Actionable Target in Advanced Prostate Cancer.

, 2021
It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically.
Bertan, C, Crespo, M, Guo, C, D'Ambrosio, M, Sharp, A, Rekowski, J, Swain, A, Carreira, S, Paschalis, A, Troiani, M, Ning, J, Gurel, B, de Bono, J, Sumanasuriya, S, PCF/SU2C International Prostate Cancer Dream Team,, Gil, V, Christova, R, Califano, A, Seed, G, Brina, D, Workman, P, Vasciaveo, A, Pereira, R, Dolling, D, Yuan, W, Flohr, P, Sheehan, B, Fowler, G, Rescigno, P, Neeb, A, Ferreira, A, Riisnaes, R, Alajati, A, Alimonti, A, Miranda, S, Buroni, L, Tunariu, N, Lambros, M, Aversa, C, Figueiredo, I, Shen, MM, Bianchini, D, Welti, J, Clarke, M, Boysen, G   +44 more
core   +1 more source

Outcomes of Surgical Treatment of Multiple Primary Colorectal and Prostate Cancer

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Aim: to evaluate the outcomes of surgical treatment of patients with multiple primary cancer of the colon and prostate.Materials and methods. An observational retrospective study was conducted at the Clinic of Coloproctology and Minimally Invasive ...
I. S. Ignatov, V. V. Balaban, E. A. Bezrukov, A. V. Nikishina, M. He, P. V. Tsarkov   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

p53 mutation, deprivation and poor prognosis in primary breast cancer [PDF]

, 2010
Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived ...
P R Quinlan, L Baker, Bourdon, J-C; id_orcid, Baker, L., C A Purdie, Birse-Stewart-Bell, L-J, Dewar, J.A., Dewar, J. A., J A Dewar, A M Thompson, Thompson, A.M., Birse-Stewart-Bell, L.-J., Purdie, C.A., Quinlan, P. R., Quinlan, P.R., Ashfield, A., C McCowan, J-C Bourdon, Jordan, L.B., Thompson, A.M, Wu, L., L-J Birse-Stewart-Bell, A Ashfield, L Wu, Patten, N., N Patten, Mccowan, C., Jordan, L. B., Bourdon, J.-C., Purdie, C. A., L B Jordan   +30 more
core   +1 more source

Multiple synchronous primary melanomas; A case report

JPRAS Open
Cutaneous melanoma is a highly aggressive form of skin cancer, responsible for >90 % of deaths related to skin tumors, despite accounting for only a small proportion of total cutaneous tumors.Cutaneous melanoma is the fifth most commonly diagnosed cancer
Nikolaj Warming, Erik Gadsbøll, Nulvin Djebbara-Bozo, Anders Munk, Helle Skyum   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cancer Trends: Cervical cancer

, 2017
In the period 2013-2015, invasive cancer of the cervix uteri (ICD10: C53) accounted for just over 1% of all invasive cancers (excluding non-melanoma skin cancer) in Ireland, with an average of 262 cases diagnosed per year.
National Cancer Registry Ireland (NCRI)
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Cancer Trends: Cancer of the liver and biliary tract

, 2010
Liver cancer consists of two main types—hepatocellular carcinoma (HCC) which accounts for about 60% of cases, and intrahepatic bile duct cholangiocarcinoma (ICC), which accounts for about 20%. The liver is one of the less common cancer sites, about 0.
National Cancer Registry Ireland (NCRI)
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source