Results 101 to 110 of about 12,302,946 (299)

The burdens of lung cancer involved multiple primary cancers and its occurring patterns–SEER Analysis between 1973 and 2006

Scientific Reports, 2017
The prognosis of malignancies has improved in recent years, subsequent primary cancers (SPCs) have become more frequent. This study investigates the patterns of lung cancer involved multiple primary cancers.
Rui Mao, Tao Chen, Fangyu Zhou, Weili Jiang, Xiaorong Yang, Zisheng Ai, Mu Li, Linlin Qin, Long Wang, Ke Fei, Chang Chen   +10 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Management of Multiple Primary Lung Cancer in Patients with Centrally Located Early Cancer Lesions [PDF]

, 2010
BackgroundPatients with centrally located early lung cancer (CLELC) are often heavy smokers with a considerably high risk of multiple primary lung cancer (MPLC) lesions; treatment strategies for such patients must preserve the cardiopulmonary function ...
Uchida, Osamu, Kajiwara, Naohiro, Tsutsui, Hidemitsu, Ishizumi, Taichirou, Ohira, Tatsuo, Ikeda, Norihiko, Usuda, Jitsuo, Ichinose, Shuji, Ohtani, Keishi, Maehara, Sachio, Hayashi, Hiroki, Ono, Shoutarou, Kato, Harubumi   +12 more
core   +1 more source

Progress in Basic Research and Clinical Treatment of Multiple Pulmonary Nodules

Chinese Journal of Lung Cancer, 2019
Lung cancer leads to the highest cancer-related morbidity and mortality worldwide. With the development of multi-slice spiral computed tomography technology and the implement of lung cancer screening, more and more lung nodules have been discovered, many
Xuejie WU, Donglai CHEN, Rongying ZHU, Yifei WANG, Chang CHEN, Yongbing CHEN, Wentao YANG   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

MULTIPLE PRIMARY LUNG CANCERS [PDF]

Chest, 2020
Amr Ismail, Meily Arevalo, Arunee Motes, John Makram, Haneen Mallah, Cinthya Carrasco Barcenas, Mohamed Zitun, David Sotello Aviles, Andres Yepes Hurtado, Kenneth Nugent   +9 more
openaire   +1 more source

[Multiple primary lung cancer].

Pneumonologia i alergologia polska, 1993
A case of a 51 year old male with multiple primary lung cancer is presented. Inspite of various gross diagnostical problems small cell lung cancer of the right lung and adenocarcinoma of the left lung were diagnosed. The patient responded favorably to the chemotherapy. Adenocarcinoma was treated surgically.
K, Lubańska, H, Okularczyk, H, Olechnowicz   +2 more
openaire   +1 more source

Multiple primary lung cancer versus intrapulmonary metastatic cancer: A case of multiple pulmonary nodules

Thoracic Cancer, 2019
A preoperative chest computed tomography examination of the right breast in a 52‐year‐old woman with breast cancer revealed multiple nodules in both lungs.
Chunquan Liu, Huawei Li, Kaikai Xu, Shuai Song, Ying He, Xianqi Cai, Xiangyu Chu, Jiandong Yang, Yong Cui   +8 more
doaj   +1 more source

Simultaneous presence of lung adenocarcinoma and malignant pleural mesothelioma: A case report

Respiratory Medicine Case Reports, 2019
The co-presence of malignant pleural mesothelioma (MPM) and lung cancer is rare. We report a 70-year-old male with exposure to asbestos. Chest computed tomography revealed a right mediastinal mass combined with an enlarged ipsilateral lymph node and left
Masatoshi Yamazoe, Hiromi Tomioka, Takahiro Kamada, Masahiro Kaneko, Eiji Katsuyama   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source