Results 121 to 130 of about 12,302,946 (299)
, 2020 Spread through air spaces (STAS) was included as a novel pattern of invasion in lung adenocarcinoma by the World Health Organization in 2015. Since then, multiple studies have investigated the association of STAS with clinicopathological and molecular ...
Toki, MI, Syrigos, KN, Harrington, K
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 2014 Molecular targeting therapeutics, such as EGFR tyrosine kinase inhibitors (TKIs), are important treatment strategies for lung cancer. Currently, the major challenge confronting targeted cancer therapies is the development of resistance. Cancer stem cells
Huang, Cheng-Po;Tsai, Meng-Feng;Chang, Tzu-Hua;Tang, Wei-Chien;Chen, Su-Yu;Lai, Hsiao-Hsuan;Lin, Ting-Yu;Yang, James Chih-Hsin;Yang, Pan-Chyr;Shih, Jin-Yuan;Lin, Shwu-Bin +1 more
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Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Cancer Trends: Cancer of unknown primary
, 2019 Between 2012 and 2016, over 450 patients per year were diagnosed with a malignant cancer where the primary site of their cancer was unspecified. These cancers were identified by the presence of metastatic disease where the cancer has spread to other ...
National Cancer Registry Ireland (NCRI)
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Erlotinib in patients with previously irradiated, recurrent brain metastases from non-small cell lung cancer: Two case reports [PDF]
, 2008 Background: With the current improvements in primary lung care, the long-term control of brain metastases becomes a clinical challenge. No established therapeutic approaches exist for cranial relapse after response to previous radiotherapy and systemic ...
Pawel, Joachim +3 more
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A Survey of the Czechoslovak Follow-up of Lung Cancer Mortality in Uranium Miners [PDF]
, 1993 The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny.
Kunz, E. +7 more
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BMC CancerMultiple primary cancers (MPC) refer to the occurrence of two or more independent primary malignant tumors in the same patient, either simultaneously or metachronously.
Yingkui Huang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Surgical Management of Postoperative Recurrence of Primary Lung Cancer
, 1988 原発性肺癌切除症例514例において, 再発・転移により再切除を施行した症例は, 胸腔内再発14例, 胸腔外再発11例の25症例で, 全切除例の4.8%に相当し, 組織型は腺癌19例(切除腺癌の8.3%), 扁平上皮癌6例(切除扁平上皮癌の3.0%)である.病期分類で, Stage Iの比率は, 胸腔内再発85.7%, 胸腔外再発36.3%で, 再切除までの期間, 予後についての各々の平均月数は, 胸腔内再発35.4ヵ月, 22.1ヵ月, 胸腔外再発8.9ヵ月, 4.6ヵ月である.In this ...
田川, 泰 +8 more
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