Results 81 to 90 of about 6,495,609 (392)

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis. [PDF]

, 2019
Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology.
Arnold, Douglas L, Barkhof, Frederik, Belachew, Shibeshih, Bernasconi, Corrado, Elliott, Colm, Fecker, Julian, Hauser, Stephen L, Kappos, Ludwig, Model, Fabian, Wei, Wei, Wolinsky, Jerry S   +10 more
core   +1 more source

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Nature, 2019
Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as oligodendrocytes both myelinate and provide metabolic support to axons.
S. Jäkel, E. Agirre, A. Falcão, D. V. Bruggen, K. Lee, I. Knuesel, D. Malhotra, C. F. Constant, Anna C. Williams, G. Castelo-Branco   +9 more
semanticscholar   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

A taxonomy of cognitive phenotypes in Multiple Sclerosis: a 1-year longitudinal study

Scientific Reports
As meaningful measure of cognitive impairment (CI), cognitive phenotypes provide an avenue for symptom management and individualized rehabilitation. Since CI is highly variable in severity and progression, monitoring cognitive phenotypes over time may be
Jessica Podda, Federica Di Antonio, Andrea Tacchino, Ludovico Pedullà, Erica Grange, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio   +7 more
doaj   +1 more source

Microbial dysbiosis and lack of SCFA production in a Spanish cohort of patients with multiple sclerosis

Frontiers in Immunology, 2022
BackgroundMultiple sclerosis (MS) is a chronic, demyelinating, and immune-mediated disease of the central nervous system caused by a combination of genetic, epigenetic, and environmental factors.
Laura Moles, Susana Delgado, Miriam Gorostidi-Aicua, Lucía Sepúlveda, Lucía Sepúlveda, Ainhoa Alberro, Leire Iparraguirre, Jose Alberto Suárez, Leire Romarate, Maialen Arruti, Maialen Arruti, Maider Muñoz-Culla, Maider Muñoz-Culla, Tamara Castillo-Triviño, Tamara Castillo-Triviño, Tamara Castillo-Triviño, David Otaegui, David Otaegui, The international Multiple Sclerosis Microbiome Study Consortium   +18 more
doaj   +1 more source

Multiple Sclerosis and Schizophrenia [PDF]

, 2017
The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (
Arneth, Borros M
core   +1 more source

Defining the clinical course of multiple sclerosis

Neurology, 2014
Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on
F. Lublin, S. Reingold, Jeffrey A. Cohen, G. Cutter, P. Sørensen, A. Thompson, J. Wolinsky, L. Balcer, B. Banwell, F. Barkhof, B. Bebo, P. Calabresi, M. Clanet, G. Comi, R. Fox, M. Freedman, A. Goodman, M. Inglese, L. Kappos, B. Kieseier, J. Lincoln, C. Lubetzki, Aaron E Miller, X. Montalban, P. O'Connor, J. Petkau, C. Pozzilli, R. Rudick, M. Sormani, O. Stüve, E. Waubant, C. Polman   +31 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Use and cost of disease-modifying therapies by Sonya Slifka Study participants: has anything really changed since 2000 and 2009? [PDF]

, 2019
Background:Disease-modifying therapies benefit individuals with relapsing forms of multiple sclerosis, but their utility remains unclear for those without relapses.
Iezzoni, Lisa I, Kinkel, R Philip, Levin, Jonathan S, Machado, Helene T, Minden, Sarah L, Rosenthal, Meredith B   +5 more
core