Results 31 to 40 of about 421,641 (311)

Epstein–Barr virus and multiple sclerosis

Nature Reviews Microbiology, 2022
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-established causal role in several cancers. Recent studies have provided compelling epidemiological and mechanistic evidence for a causal role of EBV in multiple ...
S. Soldan, P. Lieberman
semanticscholar   +1 more source

Understanding Magnetic Resonance Imaging in Multiple Sclerosis (UMIMS): Development and Piloting of an Online Education Program About Magnetic Resonance Imaging for People With Multiple Sclerosis

Frontiers in Neurology, 2022
BackgroundPeople with multiple sclerosis (pwMS) lack sufficient magnetic resonance imaging (MRI) knowledge to truly participate in frequently occurring MRI-related therapy decisions.
Magalie Freund, Insa Schiffmann, Insa Schiffmann, Anne Christin Rahn, Anne Christin Rahn, Declan Chard, Declan Chard, Carsten Lukas, Carsten Lukas, Jutta Scheiderbauer, Anna Sippel, Christoph Heesen, Christoph Heesen   +12 more
doaj   +1 more source

Updates and advances in multiple sclerosis neurotherapeutics

Neurodegenerative Disease Management, 2022
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding pipeline of agents with novel mechanisms, provide more options for patients ...
Moein Amin, Carrie M. Hersh
semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Current and Future Biomarkers in Multiple Sclerosis

International Journal of Molecular Sciences, 2022
Multiple sclerosis (MS) is a debilitating autoimmune disorder. Currently, there is a lack of effective treatment for the progressive form of MS, partly due to insensitive readout for neurodegeneration.
Jen-Pang Yang, Maysa Hamade, Qi Wu, Qin Wang, R. Axtell, S. Giri, Y. Mao-Draayer   +6 more
semanticscholar   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Organotypic Brain Slice Culture Microglia Exhibit Molecular Similarity to Acutely-Isolated Adult Microglia and Provide a Platform to Study Neuroinflammation

Frontiers in Cellular Neuroscience, 2020
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions.
Alex R. D. Delbridge, Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C. Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M. Carlile, Katelin A. Ennis, Mei Liu, Chao Sun, Normand E. Allaire, Marianna Foos, Hui-Hsin Tsai, Nathalie Franchimont, Richard M. Ransohoff, Cherie Butts, Michael Mingueneau   +19 more
doaj   +1 more source

An interactive web-based programme on relapse management for people with multiple sclerosis (POWER@MS2) - development, feasibility, and pilot testing of a complex intervention

Frontiers in Neurology, 2022
IntroductionDespite the lack of high-quality evidence regarding its long-term effectiveness, intravenous corticosteroid therapy is recommended as the standard treatment of acute multiple sclerosis relapses in Germany.
Lisa Wenzel, Lisa Wenzel, Christoph Heesen, Christoph Heesen, Julia Peper, Kristina Grentzenberg, Edeltraud Faßhauer, Jutta Scheiderbauer, Frithjof Thale, Björn Meyer, Sascha Köpke, Anne Christin Rahn, Anne Christin Rahn   +12 more
doaj   +1 more source

Therapeutic Advances in Multiple Sclerosis

Frontiers in Neurology, 2022
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system that causes significant disability and healthcare burden. The treatment of MS has evolved over the past three decades with development of new, high efficacy disease ...
Jennifer H. Yang, Torge Rempe, Natalie Whitmire, Anastasie M Dunn-Pirio, J. Graves   +4 more
semanticscholar   +1 more source