Results 91 to 100 of about 429,505 (261)

Abalign: a comprehensive multiple sequence alignment platform for B-cell receptor immune repertoires. [PDF]

Nucleic Acids Res, 2023
Zong F, Long C, Hu W, Chen S, Dai W, Xiao ZX, Cao Y.   +6 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Sequence Flow: interactive web application for visualizing partial order alignments

BMC Genomics
Background Multiple sequence alignment (MSA) has proven extremely useful in computational biology, especially in inferring evolutionary relationships via phylogenetic analysis and providing insight into protein structure and function.
Krzysztof Zdąbłasz, Anna Lisiecka, Norbert Dojer   +2 more
doaj   +1 more source

Improved mammalian family phylogeny using gap-rare multiple sequence alignment: A timetree of extant placentals and marsupials. [PDF]

Zool Res, 2023
Liu GM, Pan Q, Du J, Zhu PF, Liu WQ, Li ZH, Wang L, Hu CY, Dai YC, Zhang XX, Zhang Z, Yu Y, Li M, Wang PC, Wang X, Li M, Zhou XM.   +16 more
europepmc   +1 more source

Covariance in protein multiple sequence alignments using groups of columns [PDF]

, 2022
Kyle E. Kreth, Anthony A. Fodor
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Study of the error correction capability of multiple sequence alignment algorithm (MAFFT) in DNA storage. [PDF]

BMC Bioinformatics, 2023
Xie R, Zan X, Chu L, Su Y, Xu P, Liu W.
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Accuracy of multiple sequence alignment methods in the reconstruction of transposable element families. [PDF]

NAR Genom Bioinform, 2022
Hubley R, Wheeler TJ, Smit AFA.
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source