The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Steady-state solutions for Schrodinger equations in photonic lattice
Electronic Journal of Differential Equations, 2018 In this article, we study a nonlinear Schrodinger equation arising in optics. Firstly we prove the existence of multiple solutions of this equation. Secondly, we consider a nonlinear Schrodinger system which is intimately related to the Schrodinger ...
Wen-Long Li
doaj
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
How does framing influence preference for multiple solutions to societal problems? [PDF]
PLoS One, 2023 Wu JS, Kremen C, Zhao J.
europepmc +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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Variational Approaches for Lagrangian Discrete Nonlinear Systems
Mathematics, 2019 In this paper, we study the multiple solutions for Lagrangian systems of discrete second-order boundary value systems involving the discrete p-Laplacian operator.
Ahmed A. H. Alkhalidi +2 more
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Multiple solutions at the genomic level in response to selective breeding for high locomotor activity. [PDF]
Genetics, 2023 Hillis DA, Garland T.
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Multiple solutions for non-linear radiative mixed convective hybrid nanofluid flow over an exponentially shrinking surface. [PDF]
Sci Rep, 2023 Sarfraz M, Yasir M, Khan M.
europepmc +1 more source