Results 121 to 130 of about 17,215,808 (337)

Existence of nontrivial solutions for singular quasilinear equations with sign changing nonlinearity

Electronic Journal of Differential Equations, 2010
By an application of Bonanno's three critical point theorem, we establish the existence of a nontrivial solution to the problem $$displaylines{ -Delta_p u= mu frac{g(x)|u|^{p-2}u}{|x|^p} +lambda a(x)f(u) quad hbox{in }Omega,cr u =0quad hbox{on ...
Jagmohan Tyagi
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Multiple solutions for a class of degenerate nonlocal problems involving sublinear nonlinearities

Le Matematiche, 2014
In this article, we use the three critical points theorem by G. Bonanno [3] in order to investigate the multiplicity of solutions for some nonlocal degenerate problems.
Nguyen Thanh Chung, Hoang Quoc Toan
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Multiplicity of solutions to the sum of polyharmonic equations with critical Sobolev exponents

Electronic Journal of Differential Equations, 2015
In this article, we prove multiplicity of solutions for the sum of polyharmonic equation with critical Sobolev exponent. The proof is based upon the methods of weakly lower semi-continuous of the functionals and the Mountain Pass Lemma without (PS ...
Wei Liu, Gao Jia, Lu-Quian Guo
doaj  

Multiple Solutions in Euler’s Elastic Problem

Automation and Remote Control, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Critical points approaches for multiple solutions of a quasilinear periodic boundary value problem

Electronic Journal of Qualitative Theory of Differential Equations
Optimization problems are omnipresent in the mathematical modeling of real world systems and cover a very extensive range of applications becoming apparent in all branches of Economics, Finance, Materials Science, Astronomy, Physics, Structural and ...
Shapour Heidarkhani, Shahin Moradi, Giuseppe Caristi, Massimiliano Ferrara   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source