Results 111 to 120 of about 20,490,842 (288)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Memory Effects, Multiple Time Scales and Local Stability in Langevin Models of the S&P500 Market Correlation. [PDF]

Entropy (Basel), 2023
Wand T, Heßler M, Kamps O.
europepmc   +1 more source

Modified poisson series to implement the method of multiple scales [PDF]

, 2017
The method of multiple scales is a global perturbation technique that has resulted to be very useful in perturbed ordinary differential equations characterized by disparate time scales.
Juan F. Navarro, Navarro, Juan F.
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Stability and Hopf Bifurcation of Delayed Variable Frequency Water-Supply System

Journal of Harbin University of Science and Technology, 2018
This paper considers the mathematical model of variable frequency water supply system in the process of applying glue to artificial board. On the basis of the original linear model，the effects of time delay and the nonlinear factors are considered.
DING Yu-ting, JIANG Li, SU Lin-lin
doaj   +1 more source

The Genomic Landscapes of Desert Birds Form over Multiple Time Scales. [PDF]

Mol Biol Evol, 2022
Provost K, Shue SY, Forcellati M, Smith BT.   +3 more
europepmc   +1 more source

Corner Detection Using Multi-directional Structure Tensor with Multiple Scales

, 2020
Corners are important features for image analysis and computer vision tasks. Local structure tensors with multiple scales are widely used in intensity-based corner detectors.
Zhang, W, Sun, C
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Aberrant temporal correlations of ongoing oscillations in disorders of consciousness on multiple time scales. [PDF]

Cogn Neurodyn, 2023
Wei X, Yan Z, Cai L, Lu M, Yi G, Wang J, Dong Y.   +6 more
europepmc   +1 more source