Results 161 to 170 of about 29,886 (297)

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

A case with somatic and germline mosaicism in COL4A5 detected by multiplex ligation-dependent probe amplification in X-linked Alport syndrome. [PDF]

CEN Case Rep, 2020
Aoto Y, Kise T, Nakanishi K, Nagano C, Horinouchi T, Yamamura T, Ishiko S, Sakakibara N, Shima Y, Morisada N, Iijima K, Nozu K.   +11 more
europepmc   +1 more source

Screening of copy number variants in the 22q11.2 region of congenital heart disease patients from the São Miguel Island, Azores, revealed the second patient with a triplication [PDF]

, 2014

core   +1 more source

RNA degradomics and proteomics reveal the mechanism of dsProsβ1‐mediated proteasome targeting in Psylliodes chrysocephala

Pest Management Science, EarlyView.
RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden, Gözde Güney, Michael Rostás, Stefan Scholten   +3 more
wiley   +1 more source

Next-generation sequencing verified by multiplex ligation-dependent probe amplification to detect a new copy number variations in a child with heterozygous familial hypercholesterolemia. [PDF]

Chin Med J (Engl), 2020
Yan H, Qiu JH, Ma YN, Xiao Y, Du JB.
europepmc   +1 more source

Nanoplastics Impair GnRH Neuron Migration and Neuroendocrine Function: Emerging Players in the Pathogenesis of Reproductive Disorders

Small, EarlyView.
Little is known about the effects of polystyrene nanoplastics (PS‐NPs) on gonadotropin releasing hormone (GnRH) neurons, which control puberty onset and fertility. By applying tailored in vitro GnRH neuron models, this article shows how PS‐NPs are internalized and impact hormone secretion and cell migration, through gene expression changes. Ultimately,
Federica Amoruso, Alyssa Julia Jennifer Paganoni, Astrid Saraceni, Andrea Magnani, Alessia Brossa, Giorgio Roberto Merlo, Cristina Matei, Ruben Heinjan Willemsen, Raíssa Carneiro Rezende, Alexander Augusto de Lima Jorge, Federica Dal Bello, Patrizia Bovolin, Sasha Rose Howard, Roberto Oleari, Anna Cariboni   +14 more
wiley   +1 more source

Novel dedicator of cytokinesis 8 mutations identified by multiplex ligation-dependent probe amplification [PDF]

, 2019
Balogh, István, Csorba, Gabriella Éva, Erdős, Melinda, Kovács, Tímea, Lajszné Tóth, Beáta, Maródi, László, Pistár, Zsuzsanna   +6 more
core   +1 more source

Cas12Fold Accurately Predicts Cas12 Nuclease Structures to Enable Structure‐based Genome‐editing Engineering

Small Structures, EarlyView.
Cas12Fold, a deep‐learning framework tailored to Cas12 nucleases, uses evolutionary signals and iterative structure‐based alignment to resolve conformational complexity. This method outperforms general models in predicting key domains and states, accurately modeling enzymes such as Casλ.
Feng Xu, Zilong Zhao, Chang Liu, Meixia Yu, Ke Li, Yilin Jing, Peiyang Li, Beibei Xin, Jian Chen, Lizhu E, Jinsheng Lai, Zhijia Yang, Hainan Zhao   +12 more
wiley   +1 more source

Novel compound heterozygous variant of BSCL2 identified by whole exome sequencing and multiplex ligation‑dependent probe amplification in an infant with congenital generalized lipodystrophy. [PDF]

Mol Med Rep, 2020
Xie B, Fan X, Lei Y, Yi S, Yang Q, Wang J, Qin Z, Shen F, Luo J, Shen Y.   +9 more
europepmc   +1 more source

Tumour‐informed workflow to use ctDNA as a biomarker for risk of recurrence in head and neck cancer patients post‐treatment

VIEW, EarlyView.
Our study presents a tumour‐informed circulating tumour DNA (ctDNA) workflow designed to enhance the detection of recurrence in head and neck cancer patients, addressing key challenges such as low ctDNA tumour fractions and tumour heterogeneity. Abstract Circulating tumour DNA (ctDNA) is a promising minimally invasive biomarker for monitoring treatment
Xiaomin Huang, Paul Leo, Mhairi Clout, Lynn Fink, Jonathan Ellis, Brett G. M. Hughes, Lizbeth Kenny, Sarju Vasani, Chamindie Punyadeera   +8 more
wiley   +1 more source