Results 131 to 140 of about 1,536 (226)

Standardization of a High-Quality Methodological Framework for Long-Term Genetic Monitoring of the French Wolf Population. [PDF]

Ecol Evol
Pirog A, Duchamp C, Kaerle C, Dufaure de Citres C, Rousselot S, Lavarec J, Queney G.   +6 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

The Central-Periphery Hypothesis Revisited: Implications for Long-Term Genetic Conservation. [PDF]

Plants (Basel)
Verbylaitė R, Aravanopoulos FA, Baliuckas V, Tourvas N, Farsakoglou AM, Kotina VM, Lyrou FG, Juškauskaitė A, Petrokas R, Lygis V.   +9 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Post-copulatory competition in a social monogamy system: Sperm morphology correlates with components of reproductive success. [PDF]

PLoS One
Hawkins CE, Hahn TP, Malisch JL, Patricelli GL.   +3 more
europepmc   +1 more source

Smart-Plexer: a breakthrough workflow for hybrid development of multiplex PCR assays

, 2022
Miglietta L, Chen Y, Luo Z, Xu K, Ding N, Peng T, Moniri A, Kreitmann L, Cacho-Soblechero M, Holmes A, Georgiou P, Rodriguez-Manzano J.   +11 more
europepmc   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Advances in diagnosis of diseases causing diarrhea in newborn calves. [PDF]

Vet Res Commun
Sedky D, Ghazy AA, Abou-Zeina HAA.
europepmc   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Deep-mutational scanning libraries using Tiled-Region Exchange mutagenesis. [PDF]

G3 (Bethesda)
Kindree K, Chochinov CA, Bhachu K, Cheng Y, Caron A, McDonald M, Mamai Z, Nguyen Ba AN.   +7 more
europepmc   +1 more source