Results 61 to 70 of about 296,891 (323)

Direct fiber vector eigenmode multiplexing transmission seeded by integrated optical vortex emitters [PDF]

, 2017
Spatial modes have received substantial attention over the last decades and are used in optical communication applications. In fiber-optic communications, the employed linearly polarized modes and phase vortex modes carrying orbital angular momentum can ...
Cai, Xin-Lun, Chen, Shi, Du, Cheng, Klitis, Charalambos, Li, Shi-Mao, Liu, Jun, Mo, Qi, Sorel, Marc, Wang, An-Dong, Wang, Jian, Yu, Si-Yuan, Zhu, Long   +11 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Multiplex engineering using microRNA-mediated gene silencing in CAR T cells

Frontiers in Immunology
BackgroundMultiplex gene-edited chimeric antigen receptor (CAR) T-cell therapies face significant challenges, including potential oncogenic risks associated with double-strand DNA breaks.
Giulia Golinelli, Giulia Golinelli, John Scholler, Audrey Roussel-Gervais, Antonija Šakić, Sten Ilmjärv, Decheng Song, Khatuna Gabunia, Mei Ji, Ting J. Fan, Aasha Gupta, Mansi Deshmukh, Abdulla Berjis, Abdulla Berjis, Riccardo Cuoghi Costantini, Kimberly Apodaca, Neil C. Sheppard, Sven Kili, Massimo Dominici, Marco Alessandrini, Carl H. June, Carl H. June, Carl H. June, Bruce L. Levine   +23 more
doaj   +1 more source

Multiplexed Passive Optical Fiber Sensor Networks for Water Level Monitoring: A Review

Sensors, 2020
Water management is a critical mission required to protect the water resources that is essential in diverse industrial applications. Amongst a variety of parameters such as level (or depth), temperature, conductivity, turbidity, and pH, the water level ...
Hoon-Keun Lee, Jaeyul Choo, Joonyoung Kim   +2 more
doaj   +1 more source

Secure Air Traffic Control at the Hub of Multiplexing on the Centrifugo-Pneumatic Lab-on-a-Disc Platform

Micromachines, 2021
Fluidic larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelization of assay panels for frequent and ubiquitous bioanalytical testing in decentralized point-of-use/point-of-care settings.
Jens Ducrée
doaj   +1 more source

Weighted Multiplex Networks

PLoS ONE, 2014
One of the most important challenges in network science is to quantify the information encoded in complex network structures. Disentangling randomness from organizational principles is even more demanding when networks have a multiplex nature. Multiplex networks are multilayer systems of $N$ nodes that can be linked in multiple interacting and co ...
MENICHETTI, GIULIA, REMONDINI, DANIEL, Panzarasa P, Mondragón RJ, Bianconi G.   +4 more
openaire   +6 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Multiplexed Nanobiosensors: Current Trends in Early Diagnostics

Sensors, 2020
The ever-growing demand for fast, cheap, and reliable diagnostic tools for personalised medicine is encouraging scientists to improve existing technology platforms and to create new methods for the detection and quantification of biomarkers of clinical ...
Greta Jarockyte, Vitalijus Karabanovas, Ricardas Rotomskis, Ali Mobasheri   +3 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Ultrabright Fluorescent Silica Nanoparticles for Multiplexed Detection

Nanomaterials, 2020
Fluorescent tagging is a popular method in biomedical research. Using multiple taggants of different but resolvable fluorescent spectra simultaneously (multiplexing), it is possible to obtain more comprehensive and faster information about various ...
Saquib Ahmed M. A. Peerzade, Nadezda Makarova, Igor Sokolov   +2 more
doaj   +1 more source