Results 101 to 110 of about 168,795 (286)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Multiplicity dependence of K*(892) ±  production in pp collisions at s=13 TeV

open access: yesPhysics Letters B
The first results of K*(892) ±  production at midrapidity (|y| 
I.J. Abualrob   +1067 more
doaj   +1 more source

The Principle of Causality and Its Place in the Philosophy of Avicenna and Sadra's Wisdom [PDF]

open access: yesحکمت سینوی
The issue of causality and the question of why things happen are among the first issues that have made every thinker ponder. Avicenna and Mulla Sadra, as two philosophers committed to the principle of causality, have dealt with this issue in detail ...
Kokab Darabi   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The multiplicity of virtues and the problem of unity in Hermann Cohen’s ethics and philosophy of religion

open access: yesFilosofia Unisinos, 2021
This article discusses Hermann Cohen’s philosophy of virtues and presents, on its basis, an idea of the unity of human self-consciouness and God’s oneness.
Reiner Wiehl
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Poezja na wosku traconym w brązie 
– literackie, filozoficzne i muzyczne konteksty 
rzeźby Lidii Sztwiertni

open access: yesPostscriptum Polonistyczne, 2020
The theme of the article aims at interpreting the artistic creativity of Lidia Sztwiertnia – the sculptress from Bielsko­Biała – in the context of the philosophy of ‘multiplicity and unity of arts’.
Teresa Rączka
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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