Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. [PDF]
PLoS Biology, 2023 Microtubule-targeted agents are commonly used for cancer treatment, though many patients do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via mitotic arrest because they cause cell death following mitotic arrest in ...
Amber S Zhou +8 more
doaj +8 more sources
Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles [PDF]
Journal of Advanced ResearchIntroduction: Ultra-high static magnetic fields (SMFs) have unique advantages in improving medical and academic research. However, the research on the early embryo exposure of ultra-high SMFs is minimal, extensive exploration is indispensable in living ...
Lei Cheng +11 more
doaj +6 more sources
The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis [PDF]
Biomolecules, 2021 Mitochondrial fission and fusion cycles are integrated with cell cycle progression. Here we first re-visited how mitochondrial ETC inhibition disturbed mitosis progression, resulting in multipolar spindles formation in HeLa cells.
Huey-Jiun Ko +10 more
doaj +5 more sources
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. [PDF]
PLoS ONE, 2009 Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis ...
William T Silkworth +3 more
doaj +7 more sources
Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells. [PDF]
Oncotarget, 2016 Histone deacetylases (HDACs) play crucial roles in the initiation and progression of cancer, offering a promising target for cancer therapy. HDACs inhibitor MGCD0103 (MGCD) exhibits effective anti-tumor activity by blocking proliferation and inducing ...
Yan M +7 more
europepmc +7 more sources
Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. [PDF]
Sci Transl Med, 2014 The chemotherapy drug paclitaxel causes tumor regression and cell death by inducing high rates of chromosome missegregation on multipolar spindles.
Zasadil LM +8 more
europepmc +7 more sources
Suppressing Anaphase-Promoting Complex/Cyclosome–Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles [PDF]
Int J Mol SciPaclitaxel induces multipolar spindles at clinically relevant doses but does not substantially increase mitotic indices. Paclitaxel’s anti-cancer effects are hypothesized to occur by promoting chromosome mis-segregation on multipolar spindles leading to ...
Schuyler S, Chen H, Chang K.
europepmc +4 more sources
Two cancer cell lines utilize Myosin 10 and the kinesin HSET differentially to maintain mitotic spindle bipolarity. [PDF]
PLoS ONECancer cells often undergo mitosis possessing more than two centrosomes. To avoid a multipolar mitosis, the consequences of which are typically aneuploidy induced senescence, they must cluster their extra centrosomes to create a pseudo-bipolar spindle ...
Yang-In Yim +3 more
doaj +3 more sources
siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells [PDF]
InsectsSilkworm ovary-derived BmN4 cells rely on chromatin-induced spindle assembly to form microtubule-based square mitotic spindles that ensure accurate segregation of holocentric chromosomes during cell division.
Bing Zhang +5 more
doaj +3 more sources
The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. [PDF]
PLoS ONEThe mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function ...
Renaldo Sutanto +6 more
doaj +3 more sources