Results 1 to 10 of about 132 (90)
PLoS Biology, 2023 Microtubule-targeted agents are commonly used for cancer treatment, though many patients do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via mitotic arrest because they cause cell death following mitotic arrest in ...
Amber S Zhou +8 more
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The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis [PDF]
Biomolecules, 2021 Mitochondrial fission and fusion cycles are integrated with cell cycle progression. Here we first re-visited how mitochondrial ETC inhibition disturbed mitosis progression, resulting in multipolar spindles formation in HeLa cells.
Huey-Jiun Ko +10 more
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Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. [PDF]
PLoS ONE, 2009 Many cancer cells display a CIN (Chromosome Instability) phenotype, by which they exhibit high rates of chromosome loss or gain at each cell cycle. Over the years, a number of different mechanisms, including mitotic spindle multipolarity, cytokinesis ...
William T Silkworth +3 more
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Appropriate Mechanical Confinement Inhibits Multipolar Cell Division via Pole-Cortex Interaction
Physical Review X, 2023 Multipolar spindles are very rare in normal tissues, but they are much more prevalent in many tumors, which might be induced by the mechanical confinements from overcrowding microenvironments in tumors.
Longcan Cheng +3 more
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Effect of change in spindle structure on proliferation inhibition of osteosarcoma cells and osteoblast under simulated microgravity during incubation in rotating bioreactor. [PDF]
PLoS ONE, 2013 In order to study the effect of microgravity on the proliferation of mammalian osteosarcoma cells and osteoblasts, the changes in cell proliferation, spindle structure, expression of MAD2 or BUB1, and effect of MAD2 or BUB1 on the inhibition of cell ...
Lijun Wei +6 more
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PLoS Genetics, 2022 During mitosis, centrosomes serve as microtubule organizing centers that guide the formation of a bipolar spindle. However, oocytes of many species lack centrosomes; how meiotic spindles establish and maintain these acentrosomal poles remains poorly ...
Gabriel Cavin-Meza +6 more
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Genome Biology, 2022 Background During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental biological tenet, we demonstrate here that parental genomes can segregate
Tine De Coster +13 more
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eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
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Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. [PDF]
PLoS ONE, 2007 BACKGROUND:The Ewing sarcoma breakpoint region 1 gene (EWSR1), also known as EWS, is fused to a number of different partner genes as a result of chromosomal translocation in diverse sarcomas.
Mizuki Azuma +3 more
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Scientific Reports, 2021 We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification.
Dilan Boodhai Jaunky +5 more
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