Results 91 to 100 of about 153,409 (229)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas [PDF]

, 2016
Background Amplified centrosomes are widely recognized as a hallmark of cancer. Although supernumerary centrosomes would be expected to compromise cell viability by yielding multipolar spindles that results in death-inducing aneuploidy, cancer cells ...
Aneja, Ritu, Cantuaria, Guilherme, Choi, Da Hoon, Gupta, Meenakshi V., Kaur, Ramneet, Klimov, Sergey, Mitra, Anirban K., Mittal, Karuna, Pawar, Shrikant, Rida, Padmashree C. G., Sams, Ralph   +10 more
core   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

PLoS ONE
The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic transformation affects spindle mechanics and function ...
Renaldo Sutanto, Lila Neahring, Andrea Serra Marques, Mauricio Jacobo Jacobo, Seda Kilinc, Andrei Goga, Sophie Dumont   +6 more
doaj   +1 more source

LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. [PDF]

PLoS Genetics, 2015
Skeletal dysplasias are a common, genetically heterogeneous cause of short stature that can result from disruptions in many cellular processes. We report the identification of the lesion responsible for skeletal dysplasia and male infertility in the ...
Krista A Geister, Michelle L Brinkmeier, Leonard Y Cheung, Jennifer Wendt, Melissa J Oatley, Daniel L Burgess, Kenneth M Kozloff, James D Cavalcoli, Jon M Oatley, Sally A Camper   +9 more
doaj   +1 more source

Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer [PDF]

, 2013
The unique ability of centrosomes to nucleate and organize microtubules makes them unrivaled conductors of important interphase processes, such as intracellular payload traffic, cell polarity, cell locomotion, and organization of the immunologic synapse.
Pihan, German A.
core   +2 more sources

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]

, 2020
BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine, Hewit, Kay, James, Daniel, Leung, Hing, Munnings-Tomes, Sophie, Patel, Rachana, Rushworth, Linda, Shanks, Emma, Somani, Sukrut, Straube, Anne   +9 more
core   +3 more sources

Ecotoxicological Evaluation of the Antimicrobial Butylparaben in Edaphic Organisms Using Multiple Biomarkers

Environmental Toxicology, EarlyView.
ABSTRACT Butylparaben (BuP) recurrently contaminates soils worldwide, mainly by incorporating sewage sludge into cultivated areas, using wastewater in irrigation, and leaching contaminated soils. However, there are few studies on the ecotoxicological effects of this paraben on edaphic organisms.
Lorena Maihury Santos Tsubouchi, Edson Araújo de Almeida, Diane Scapin, Anna Karolina Gomes Oliveira, Cassiano Aparecido de Souza, Diego Espirito Santo, Carmem Lúcia Henrich, Ana Elisa Maehashi, Gideã Taques Tractz, Craig Allan Downs, Osvaldo Valarini Junior, Regiane da Silva Gonzalez, Elisângela Düsman, Ana Paula Peron   +13 more
wiley   +1 more source

Ecotoxicological Evaluation of Organic Sunscreens Used Worldwide, Alone and in Mixture, on Terrestrial Plants

Environmental Toxicology, EarlyView.
ABSTRACT The environmental hazards of sunscreens are discussed worldwide. However, there are few ecotoxicological studies on these compounds alone for edaphic organisms, and none for their mixtures. Avobenzone (1 and 10 ng/L), octocrylene (10 and 100 μg/L), and oxybenzone (2 and 20 μg/L), alone and in binary combinations (between the lowest and the ...
Diego Espirito Santo, Edson Araújo de Almeida, Elisângela Dusman, A. C. Downs, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +6 more
wiley   +1 more source

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

Molecular Cancer, 2011
Background Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation ...
Asteriti Italia A, Giubettini Maria, Lavia Patrizia, Guarguaglini Giulia   +3 more
doaj   +1 more source