Results 91 to 100 of about 1,789 (148)
A SUMOylation Motif in Aurora-A: Implications in Spindle Dynamics and Oncogenesis
Frontiers in Oncology, 2011 Aurora-A is a serine/threonine kinase that plays critical roles in centrosome maturation, spindle dynamics and chromosome orientation and is frequently found overexpressed in human cancers.
Ignacio ePérez de Castro +8 more
doaj +1 more source
Stem Cell Research & Therapy, 2023 Background Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD).
Marija Zekušić +17 more
doaj +1 more source
Gap junction plasticity can lead to spindle oscillations [PDF]
arXiv, 2017 Patterns of waxing and waning oscillations, called spindles, are observed in multiple brain regions during sleep. Spindle are thought to be involved in memory consolidation. The origin of spindle oscillations is ongoing work but experimental results point towards the thalamic reticular nucleus (TRN) as a likely candidate.
arxiv
Mechanical stability of bipolar spindle assembly [PDF]
, 2016 Assembly and stability of mitotic spindle is governed by the interplay of various intra-cellular forces, e.g. the forces generated by motor proteins by sliding overlapping anti-parallel microtubules (MTs) polymerized from the opposite centrosomes, the interaction of kinetochores with MTs, and the interaction of MTs with the chromosomes arms.
arxiv +1 more source
Clinical Case Reports, Volume 13, Issue 1, January 2025.ABSTRACT Wilms' tumor (WT), also known as nephroblastoma, is a malignant embryonal kidney tumor composed of embryonic cells and is the most prevalent tumor among children, but isolated cases occur infrequently in the adult population. Adult WT is defined according to the criteria of Kilton, Matthews, and Cohen, which comprise age above 15 years and ...
Amini Mitamo Alexandre +7 more
wiley +1 more source
Cell Proliferation, Volume 58, Issue 1, January 2025.CENP‐E deletion results in chromosome misalignment, spindle pole disorganization and chromosome instability in mitosis. CENP‐E is essential for kinetochore‐microtubule attachment, spindle pole organization and the regulation of spindle assembly checkpoint during cell division.
Jie Chen +8 more
wiley +1 more source
The FASEB Journal, Volume 38, Issue 24, 31 December 2024.DeSUMOylating isopeptidase 1 (DESI1), a member of the second class of SUMO protease, maintains the expression level of Aurora B to promote the spindle assembly checkpoint. DESI1 is required for the activity of FoxM1 in the transcription of mitotic regulators including Aurora B.
Yuki Ikeda +3 more
wiley +1 more source
Logspace computations for Garside groups of spindle type [PDF]
arXiv, 2013 M. Picantin introduced the notion of Garside groups of spindle type, generalizing the 3-strand braid group. We show that, for linear Garside groups of spindle type, a normal form and a solution to the conjugacy problem are logspace computable. For linear Garside groups of spindle type with homogenous presentation we compute a geodesic normal form in ...
arxiv
Isoflavone Derivatives as Potential Anticancer Agents: Synthesis and Bioactivity Studies
ChemMedChem, Volume 19, Issue 23, December 2, 2024.Several isoflavone analogues with potential anticancer activities have been discovered. They include tubulin polymerase, kinases (EGFR, PI3Kδ, PI3 Kγ) HDACs and angiogenesis inhibitors. They also block signalling pathways such as Hedgehog, PI3 K/AKT/mTOR, MAPK/Wnt, EGFR/PI3 K/Akt/Bad, EGFR/ERK and EGFR/PI3 K/Akt/b‐catenin.
Mamoalosi A. Selepe
wiley +1 more source
Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast [PDF]
arXiv, 2016 Kinesin-8 motor proteins destabilize microtubules. Their absence during cell division is associated with disorganized mitotic chromosome movements and chromosome loss. Despite recent work studying effects of kinesin 8s on microtubule dynamics, it remains unclear whether the kinesin-8 mitotic phenotypes are consequences of their effect on microtubule ...
arxiv