Results 91 to 100 of about 147,555 (174)

Extract of bulbus of Fritillaria cirrhosa induces spindle multipolarity in human-derived colonic epithelial NCM460 cells through promoting centrosome fragmentation [PDF]

, 2021
Xihan Guo, Chunlei Wang, Weimeng Tian, Xueqin Dai, Juan Ni, Xiayu Wu, Xu Wang   +6 more
openalex   +1 more source

The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction.

PLoS ONE, 2011
Human Tubulin Binding Cofactor C (TBCC) is a post-chaperonin involved in the folding and assembly of α- and β-tubulin monomers leading to the release of productive tubulin heterodimers ready to polymerize into microtubules.
Ma Flor Garcia-Mayoral, Raquel Castaño, Monica L Fanarraga, Juan Carlos Zabala, Manuel Rico, Marta Bruix   +5 more
doaj   +1 more source

Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas

Neoplasia: An International Journal for Oncology Research, 2008
The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways.
Gilson S. Baia, Stefano Stifani, Edna T. Kimura, Michael W. McDermott, Russell O. Pieper, Anita Lal   +5 more
doaj   +1 more source

Loss of CHFR in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting the Mitotic Spindle Assembly Checkpoint

Neoplasia: An International Journal for Oncology Research, 2008
CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the role of CHFR in genomic stability, by siRNA, we decreased its expression in genomically stable ...
Lisa M. Privette, Jingly Fung Weier, Ha Nam Nguyen, Xiaochun Yu, Elizabeth M. Petty   +4 more
doaj   +1 more source

Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction

Cell Death and Disease
Unlike normal cells, cancer cells frequently exhibit supernumerary centrosomes, leading to formation of multipolar spindles that can trigger cell death.
B. Kalkan, Selahattin Can Ozcan, Enes Cicek, Mehmet Gonen, Ceyda Açilan   +4 more
semanticscholar   +1 more source

Microcystin-LR and Cylindrospermopsin Induced Alterations in Chromatin Organization of Plant Cells

Marine Drugs, 2013
Cyanobacteria produce metabolites with diverse bioactivities, structures and pharmacological properties. The effects of microcystins (MCYs), a family of peptide type protein-phosphatase inhibitors and cylindrospermopsin (CYN), an alkaloid type of protein
Gábor Vasas, Márta M-Hamvas, Csaba Máthé   +2 more
doaj   +1 more source

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

PLoS Genetics, 2012
Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been associated with primary microcephaly and the microcephalic primordial dwarfism disorder Seckel ...
Rebecca E McIntyre, Pavithra Lakshminarasimhan Chavali, Ozama Ismail, Damian M Carragher, Gabriela Sanchez-Andrade, Josep V Forment, Beiyuan Fu, Martin Del Castillo Velasco-Herrera, Andrew Edwards, Louise van der Weyden, Fengtang Yang, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Jeanne Estabel, Ferdia A Gallagher, Darren W Logan, Mark J Arends, Stephen H Tsang, Vinit B Mahajan, Cheryl L Scudamore, Jacqueline K White, Stephen P Jackson, Fanni Gergely, David J Adams   +23 more
doaj   +1 more source

Chromosomal instability increases radiation sensitivity

bioRxiv
Continuous chromosome missegregation over successive mitotic divisions, known as chromosomal instability (CIN), is common in cancer. Increasing CIN above a maximally tolerated threshold leads to cell death due to loss of essential chromosomes.
P. Cosper, M. Paracha, Kathryn M. Jones, Laura C. F. Hrycyniak, Les Henderson, Ava Bryan, D. Eyzaguirre, Emily McCunn, Elizabeth Boulanger, Jun Wan, K. Nickel, Vanessa L Horner, Rong Hu, Paul M. Harari, R. Kimple, B. Weaver   +15 more
semanticscholar   +1 more source

B-type plexins regulate mitosis via RanGTPase

bioRxiv
Aberrant mitosis can result in aneuploidy and cancer. The small GTPase, Ran, is a key regulator of mitosis. B-type Plexins regulate Ran activity by acting as RanGTPase activating proteins (GAPs) and have been implicated in cancer progression.
Nicholus Mukhwana, Ritu Garg, Magali Williamson   +2 more
semanticscholar   +1 more source

Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts

Ecotoxicology and Environmental Safety
Deoxynivalenol (DON), commonly known as vomitoxin, is a mycotoxin produced by fungi and is frequently found as a contaminant in various cereal-based food worldwide.
Zhenzhen Wang, Huimin Duan, Xue You, Qian Peng, Ningyang Yuan, Rula Sha, Zhiqin Xie, Ying Feng   +7 more
doaj   +1 more source