Results 111 to 120 of about 153,409 (229)
Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X [PDF]
, 2014 Mitotic spindles are microtubule-based structures, but increasing evidence indicates that filamentous actin (F-actin) and F-actin-based motors are components of these structures.
Chan, P.-C. +4 more
core +2 more sources
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. [PDF]
, 2012 Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4).
Bettencourt-Dias, Monica +10 more
core +4 more sources
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Canine phaeochromocytomas (PCCs) are neuroendocrine tumours with malignant potential. Metastatic disease remains the sole definitive evidence of malignancy. Histopathological criteria to predict long‐term survival have not been established in dogs.
Marit F. van den Berg +6 more
wiley +1 more source
Cytoplasmic MTOCs control spindle orientation for asymmetric cell division in plants [PDF]
, 2017 Proper orientation of the cell division axis is critical for asymmetric cell divisions that underpin cell differentiation. In animals, centrosomes are the dominant microtubule organizing centers (MTOC) and play a pivotal role in axis determination by ...
Boruc, Joanna +7 more
core +2 more sources
Aging Cell, Volume 25, Issue 2, February 2026.A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang +14 more
wiley +1 more source
Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. [PDF]
PLoS ONE, 2011 BACKGROUND: Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle ...
Marta Mattiuzzo +6 more
doaj +1 more source
Distinct firing patterns of identified basket and dendrite-targeting interneurons in the prefrontal cortex during hippocampal theta and local spindle oscillations [PDF]
, 2009 The medial prefrontal cortex is involved in working memory and executive control. However, the collective spatiotemporal organization of the cellular network has not been possible to explain during different brain states.Weshow that pyramidal cells in ...
Hartwich K +2 more
core +2 more sources
Cancer Science, Volume 117, Issue 2, Page 377-392, February 2026.MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang +4 more
wiley +1 more source
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype [PDF]
, 2007 Background: Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN).
AMATO, Angela +3 more
core +2 more sources