Results 111 to 120 of about 1,789 (148)
BMC Bioinformatics, 2017 Background Cell division (mitosis) results in the equal segregation of chromosomes between two daughter cells. The mitotic spindle plays a pivotal role in chromosome alignment and segregation during metaphase and anaphase. Structural or functional errors
Matloob Khushi +5 more
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Automated three-dimensional single cell phenotyping of spindle dynamics, cell shape, and volume [PDF]
arXiv, 2015 We present feature finding and tracking algorithms in 3D in living cells, and demonstrate their utility to measure metrics important in cell biological processes. We developed a computational imaging hybrid approach that combines automated three-dimensional tracking of point-like features with surface determination from which cell (or nuclear) volume ...
arxiv
Improved Multipolar Poincaré-Hardy inequalities on Cartan-Hadamard Manifolds [PDF]
arXiv, 2018 We prove a family of improved multipolar Poincar\'e-Hardy inequalities on Cartan-Hadamard manifolds. For suitable configurations of poles, these inequalities yield an improved multipolar Hardy inequality and an improved multipolar Poincar\'e inequality such that the critical unipolar singular mass is reached at any pole.
arxiv
Dynamic stability of spindles controlled by molecular motor kinetics [PDF]
arXiv, 2006 We analyze the role of the force-dependent kinetics of motor proteins in the stability of antiparallel arrays of polar filaments, such as those in the mitotic spindle. We determine the possible stable structures and show that there exists an instability associated to the collective behavior of motors that leads to the collapse of the spindle.
arxiv
Microtubule Dynamics and Oscillating State for Mitotic Spindle [PDF]
arXiv, 2010 We present a physical mechanism that can cause the mitotic spindle to oscillate. The driving force for this mechanism emerges from the polymerization of astral microtubules interacting with the cell cortex. We show that Brownian ratchet model for growing microtubules reaching the cell cortex, mediate an effective mass to the spindle body and therefore ...
arxiv
MoleculesDelaying mitotic cell cycle progression has been proposed as a strategy to potentiate the effects of anti-mitotic anti-cancer drugs that induce multipolar mitotic spindles. Toward this end, we have performed an in silico docking screen targeting anaphase-
Scott C. Schuyler +4 more
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A Clinical Overview of Centrosome Amplification in Human Cancers
International Journal of Biological Sciences, 2011 The turn of the 21st century had witnessed a surge of interest in the centrosome and its causal relation to human cancer development - a postulate that has existed for almost a century.
Jason Yongsheng Chan
doaj
Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts
Ecotoxicology and Environmental SafetyDeoxynivalenol (DON), commonly known as vomitoxin, is a mycotoxin produced by fungi and is frequently found as a contaminant in various cereal-based food worldwide.
Zhenzhen Wang +7 more
doaj