Exploration, Volume 5, Issue 6, December 2025.This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Fangfang Liu +15 more
wiley +1 more source
Length-dependent anisotropic scaling of spindle shape [PDF]
, 2014 Spindle length varies dramatically across species and during early development to segregate chromosomes optimally. Both intrinsic factors, such as regulatory molecules, and extrinsic factors, such as cytoplasmic volume, determine spindle length scaling ...
Besson, Sébastien +2 more
core +5 more sources
Seh1 targets GATOR2 and Nup153 to mitotic chromosomes [PDF]
, 2018 In metazoa the Nup107-160 nucleoporin Y complex plays a major role in formation of the nuclear pore complex in interphase and is localised to kinetochores in mitosis.
Earnshaw, W C +4 more
core +1 more source
3D Neuro-electronic interface devices for neuromuscular control: Design studies and realisation steps [PDF]
, 1995 In order to design the shape and dimensions of new 3D multi-microelectrode information transducers properly, i. e. adapted to the scale of information delivery to and from peripheral nerve fibres, a number of studies were, and still are, being performed ...
Frieswijk, Theo A. +4 more
core +2 more sources
Genetic and molecular characterization of the human osteosarcoma 3AB-OS cancer stem cell line: a possible model for studying osteosarcoma origin and stemness. [PDF]
, 2013 Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical to halt cancer and improve patient survival. Osteosarcoma is an aggressive tumor affecting adolescents, for which there is no second-line chemotherapy ...
AMODEO, Valeria +11 more
core +1 more source
The ploidy-conveyor of mature hepatocytes as a source of genetic variation
Nature, 2010 Mononucleated and binucleated polyploid hepatocytes (4n, 8n, 16n and higher) are found in all mammalian species, but the functional significance of this conserved phenomenon remains unknown.
A. Duncan +7 more
semanticscholar +1 more source
PLoS ONE, 2011 Human Tubulin Binding Cofactor C (TBCC) is a post-chaperonin involved in the folding and assembly of α- and β-tubulin monomers leading to the release of productive tubulin heterodimers ready to polymerize into microtubules.
Ma Flor Garcia-Mayoral +5 more
doaj +1 more source
The E1B19K-deleted oncolytic adenovirus mutant Ad Delta 19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11 [PDF]
, 2016 This study was supported by a generous grant from the UK charity Pancreatic Cancer Research Fund (PCRF) and by the BCI CRUK Centre Grant [grant number C16420/A18066]
Cherubini, G +3 more
core +1 more source
Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features [PDF]
, 2013 Palisade endings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primates. They have long been postulated to be proprioceptors. It was recently demonstrated that palisade endings are cholinergic and that in monkeys
Davis López de Carrizosa, María América +5 more
core +1 more source
Notch Activation Is Associated with Tetraploidy and Enhanced Chromosomal Instability in Meningiomas
Neoplasia: An International Journal for Oncology Research, 2008 The Notch signaling cascade is deregulated in diverse cancer types. Specific Notch function in cancer is dependent on the cellular context, the particular homologs expressed, and cross-talk with other signaling pathways.
Gilson S. Baia +5 more
doaj +1 more source