Results 141 to 150 of about 147,555 (174)

A Universal Scaling Law for Mitotic Spindles Driven by Chromosome Crowding

Tolić I, Gudlin L, Vukusic K, Novak M, Trupinić M, Ljulj M, Dundović I, Petelinec A, Petrušić L, Hertel A, Ravesteyn Tv, Trakala M, Kops G, Storchová Z, Tambača J, Pavin N.   +15 more
europepmc   +1 more source

Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles

Biochemical and Biophysical Research Communications, 2005
We previously identified a novel microtubule-destabilizing motif in CPAP that can disassemble microtubules. To examine further the CPAP function in human cells, we used siRNA to knockdown its expression. Our results showed that CPAP depletion arrested cells in mitosis and induced apoptosis.
Jun‐Hung Cho, Chih-Jui Chang, Chiung-Ya Chen, Tang K. Tang   +3 more
semanticscholar   +4 more sources

Induction of multipolar spindles by X-radiation in mammalian cells in vitro

Experimental Cell Research, 1963
Coverslip cultures of mammalian cells in logarithmic growth were exposed to 200, 400, and 600 r x radiation and fixed at 12-hr intervals up to 108 hr after exposure. The generation time of untreated cells was about 24 hr. Mitotic figures were scored and classed according to their number of poles at different intervals after irradiation.
A.G. Levis, G. Marin
semanticscholar   +5 more sources

Induction of structural and numerical changes of chromosome, centrosome abnormality, multipolar spindles and multipolar division in cultured Chinese hamster V79 cells by exposure to a trivalent dimethylarsenic compound

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2003
Dimethylarsine iodide (DMI) was used as a model compound of trivalent dimethylarsenicals [DMA(III)], and the biological effects were extensively investigated in cultured Chinese hamster V79 cells. When the cytotoxic effects of DMA(III) were compared with those of inorganic arsenite and dimethylarsinic acid [DMA(V)], DMA(III) was about 10,000 times more
Takafumi Ochi, Tosihide Suzuki, Hideo Isono, Claudia Schlagenhaufen, Walter Goessler, Takeki Tsutsui   +5 more
semanticscholar   +5 more sources

Induction of centrosome injury, multipolar spindles and multipolar division in cultured V79 cells exposed to dimethylarsinic acid: role for microtubules in centrosome dynamics

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000
Role for microtubules in the induction of multiple microtubule organizing centers (MTOCs) and multipolar spindles by dimethylarsinic acid (DMAA), a methylated derivative of inorganic arsenics, was investigated with respect to the effects of microtubule disruption and reorganization.
Takafumi Ochi
semanticscholar   +5 more sources

Cytotoxicity of Atropisomeric [1,1'-Binaphthalene]-2,2'-Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure-Activity Relationships, and Mechanism.

ChemMedChem, EarlyView.
Binaphthyls usually serve as key chiral ligands in catalysts for asymmetric syntheses, having been reported in thousands of published reactions.
Malte Eichelbaum, P. Bednarski
semanticscholar   +2 more sources

Role of mitotic motors, dynein and kinesin, in the induction of abnormal centrosome integrity and multipolar spindles in cultured V79 cells exposed to dimethylarsinic acid

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2002
The role of microtubule-based motors in the induction of abnormal centrosome integrity by dimethylarsinic acid (DMAA) was investigated with the use of monastrol, a specific inhibitor of mitotic kinesin, and vanadate, an inhibitor of dynein ATPase. Cytoplasmic dynein co-localized with multiple foci of gamma-tubulin in mitotic cells arrested by DMAA ...
Takafumi Ochi
semanticscholar   +5 more sources

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Multipolar spindles after endoreduplication.

Experimental Cell Research, 1966
W. Schmid
semanticscholar   +5 more sources

Induction of multipolar spindles by single X-irradiated sperm

Experientia, 1959
Une experience simple de dilution etablit que les clivages multipolaires des œufs de oursins resultent de l'insemination par des spermatozoides individuels qui ont ete soumis aux rayons X.
R. Rustad
semanticscholar   +4 more sources