Results 151 to 160 of about 147,555 (174)

Origin of the Cones of the Multipolar Spindle in Gladiolus [PDF]

Botanical Gazette, 1900
The above observations may be summarized as follows: As nuclear division approaches, a granular zone accumulates about the nucleus. This zone in every respect resembles the perikaryoplasm so characteristic of the pollen mother cells of Cobaea. A close network or felted zone of kinoplasmic fibers is formed immediately outside of and completely ...
ANSTRUTHER A. LAWSON
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Bisphenol A disrupts microtubules and induces multipolar spindles in dividing root tip cells of the gymnosperm Abies cephalonica.

Chemosphere, 2016
The effects of bisphenol A (BPA), an endocrine chemical disruptor extensively used in the plastic and epoxy resin industry, on dividing root tip cells of the gymnosperm Abies cephalonica Loudon were investigated by confocal laser scanning microscopy after tubulin and endoplasmic reticulum immunolocalization and DNA staining.
I. Adamakis, E. Panteris, E. Eleftheriou
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Induction of multiple microtubule-organizing centers, multipolar spindles and multipolar division in cultured V79 cells exposed to diethylstilbestrol, estradiol-17beta and bisphenol A.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999
Inducibility of multipolar spindles and multipolar division by diethylstilbestrol (DES) and estradiol-17beta (E2) was investigated in terms of the mechanism of induction of aneuploidy by the estrogens. DES, E2 and bisphenol A (Bp-A), a structural analogue of DES, caused mitotic arrest and aberrant spindles, such as tripolar and multipolar spindles, in ...
T. Ochi
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Centrosomal amplification and spindle multipolarity in cancer cells

Seminars in Cancer Biology, 2004
Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell.
William S. Saunders
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Spindle Multipolarity Is Prevented by Centrosomal Clustering

Science, 2005
Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity.
William S. Saunders, Diane R. Hoffelder, Nicholas J. Quintyne, Janet E. Reing, Susanne M. Gollin   +4 more
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Methylmercury, but not inorganic mercury, causes abnormality of centrosome integrity (multiple foci of γ-tubulin), multipolar spindles and multinucleated cells without microtubule disruption in cultured Chinese hamster V79 cells

Toxicology, 2002
Takafumi Ochi
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Structure–effect relationship in the induction of mitotic phase-specific abnormality of centrosome integrity and multipolar spindles by steroidal estrogens and their derivatives in cultured mammalian cells

Journal of Steroid Biochemistry and Molecular Biology, 2001
Takafumi Ochi, Taiko Oda
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Mitotic spindle multipolarity without centrosome amplification

Nature Cell Biology, 2014
Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell division. Multipolar spindles are often seen in human cancers and are usually associated with supernumerary centrosomes that result from centrosome overduplication or cytokinesis failure.
Helder Maiato, Elsa Logarinho
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v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells

Cellular Signalling, 2016
The protein-tyrosine kinase, c-Src, is involved in a variety of signaling events, including cell division. We have reported that v-Src, which is a mutant variant of the cellular proto-oncogene, c-Src, causes delocalization of Aurora B kinase, resulting in a furrow regression in cytokinesis and the generation of multinucleated cells. However, the effect
Keiko Kakae, Masayoshi Ikeuchi, Takahisa Kuga, Youhei Saito, Naoto Yamaguchi, Yuji Nakayama   +5 more
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Distribution of pericentriolar material in multipolar spindles induced by colcemid treatment in chinese hamster ovary cells [PDF]

Journal of Cell Science, 1988
ABSTRACT Mitotic Chinese hamster ovary cells were obtained by treatment with microtubule drugs under various conditions, and the shape of spindles was analysed by phase-contrast microscopy of isolated spindles, and by indirect immunofluorescence staining of whole mitotic cells with anti-tubulin antibody.
Caterina Sellitto, Ryoko Kuriyama
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