Molecular Biology of the Cell, 2023 During mitosis, equal partitioning of chromosomes into two daughter cells requires assembly of a bipolar mitotic spindle. Because the spindle poles are each organized by a centrosome in animal cells, centrosome defects can lead to monopolar or multipolar
Xiaochu Li +4 more
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YAKUGAKU ZASSHI, 2016 Toxicological studies of arsenic compounds were conducted in cultured mammalian cells to investigate the effects of glutathione (GSH) depletion. Dimethylarsinate DMA(V) was not cytotoxic in cells depleted of GSH, but was found to be cytotoxic when GSH ...
Takafumi Ochi
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MULTIPOLAR SPINDLES IN HUMAN CANCER CELLS [PDF]
Hereditas, 2010 Eeva Therman, S Timonen
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A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi‐1 [PDF]
Molecular Oncology, 2014 Traditional antimitotic drugs for cancer chemotherapy often have undesired toxicities to healthy tissues, limiting their clinical application. Developing novel agents that specifically target tumor cell mitosis is needed to minimize the toxicity and improve the efficacy of this class of anticancer drugs.
Jingnan Wang +6 more
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Correction: Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. [PDF]
PLoS BiolZhou AS +8 more
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Induction of Multipolar Spindles in the Meiosis of <i>Triticum aestivum</i> as Effected by Acetone
CYTOLOGIA, 1966 In the present investigation, the treatment of pollen mother cells of Triticum aestivum with acetone provided an excellent material for multipolarity. It was possible to follow the formation of the spindle fibre apparatus in the case of multipolar anaphases.
A. Kabarity
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Delocalization of the Microtubule Motor Dynein from Mitotic Spindles by the Human Papillomavirus E7 Oncoprotein Is Not Sufficient for Induction of Multipolar Mitoses [PDF]
Cancer Research, 2008 Abstract Dynein is a minus end–directed microtubule motor that transports numerous cargoes throughout the cell. During mitosis, dynein motor activity is necessary for the positioning of spindle microtubules and has also been implicated in inactivating the spindle assembly checkpoint.
Christine Nguyen +2 more
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Data from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer [PDF]
Cancer Research, 2023 Abstract PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to targeting poly(ADP-ribose) generating PARP,
Zebin Wang +24 more
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Induction of Spindle Multipolarity by Centrosomal Cluster Inhibition [PDF]
Analytical Cellular Pathology, 2008 Version of ...
Alwin Krämer +2 more
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CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer. [PDF]
Cancer ResDrugs that perturb microtubules are commonly used to treat breast cancers of all subtypes in both early stage and metastatic disease, but they are only effective in approximately 50% of patients.
Tucker JB +5 more
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