Results 11 to 20 of about 153,409 (229)

Induction of Aneuploidy, Centrosome Abnormality, Multipolar Spindle, and Multipolar Division in Cultured Mammalian Cells Exposed to an Arsenic Metabolite, Dimethylarsinate

YAKUGAKU ZASSHI, 2016
Toxicological studies of arsenic compounds were conducted in cultured mammalian cells to investigate the effects of glutathione (GSH) depletion. Dimethylarsinate DMA(V) was not cytotoxic in cells depleted of GSH, but was found to be cytotoxic when GSH ...
Takafumi Ochi
semanticscholar   +5 more sources

A fine balance among key biophysical factors is required for recovery of bipolar mitotic spindle from monopolar and multipolar abnormalities

Molecular Biology of the Cell, 2023
During mitosis, equal partitioning of chromosomes into two daughter cells requires assembly of a bipolar mitotic spindle. Because the spindle poles are each organized by a centrosome in animal cells, centrosome defects can lead to monopolar or multipolar
Xiaochu Li, Mathew Bloomfield, Alexandra Bridgeland, Daniela Cimini, Jing Chen   +4 more
semanticscholar   +6 more sources

MULTIPOLAR SPINDLES IN HUMAN CANCER CELLS [PDF]

Hereditas, 2010
Eeva Therman, S Timonen
semanticscholar   +3 more sources

Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance [PDF]

Nature Communications
SSNA1 is a fibrillar protein involved in dynamic microtubule remodeling, including nucleation, co-polymerization, and microtubule branching. The underlying molecular mechanism has remained unclear due to a lack of structural information.
Lorenzo Agostini, Jason A. Pfister, Nirakar Basnet, Jienyu Ding, Rui Zhang, Christian Biertümpfel, Kevin F. O’Connell, Naoko Mizuno   +7 more
doaj   +3 more sources

siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells

Insects
Silkworm ovary-derived BmN4 cells rely on chromatin-induced spindle assembly to form microtubule-based square mitotic spindles that ensure accurate segregation of holocentric chromosomes during cell division.
Bing Zhang, Camilo Ayra-Pardo, Xiaoning Liu, Meiting Song, Dandan Li, Yunchao Kan   +5 more
doaj   +2 more sources

Capturing aberrant cell behaviors producing defects in human embryos via live imaging. [PDF]

Sci Adv
The generation of human embryos in vitro has revolutionized reproductive medicine, and also made it possible to study fundamental aspects of early human development.
Akizawa H, Domingo-Muelas A, Pardo-Figuerez M, Hernandez B, Ardestani G, Skory RM, Venturas M, Tetlak P, Bissiere S, Sakkas D, Simon C, Plachta N.   +11 more
europepmc   +2 more sources

Cytotoxicity of Atropisomeric [1,1'-Binaphthalene]-2,2'-Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure-Activity Relationships, and Mechanism. [PDF]

ChemMedChem
Binaphthyls usually serve as key chiral ligands in catalysts for asymmetric syntheses, having been reported in thousands of published reactions.
Eichelbaum M, Bednarski PJ.
europepmc   +2 more sources

Induction of Spindle Multipolarity by Centrosomal Cluster Inhibition

Analytical Cellular Pathology, 2008
Version of ...
Alwin Krämer, Marc S. Raab, Blanka Rebacz   +2 more
  +8 more sources

CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer. [PDF]

Cancer Res
Drugs that perturb microtubules are commonly used to treat breast cancers of all subtypes in both early stage and metastatic disease, but they are only effective in approximately 50% of patients.
Tucker JB, Carlsen CL, Scribano CM, Pattaswamy SM, Burkard ME, Weaver BA.   +5 more
europepmc   +2 more sources

Testicular Hypoplasia with Multipolar Spindle Formation in the Spermiocytes of the Bull [PDF]

Acta Veterinaria Scandinavica, 1961
Formation of multipolar nuclear spindles in spermiocytes has been demonstrated in three highly in-bred and closely related bulls with a type of testicular hypoplasia which can be summarised as arrested spermiogenesis. The spindle abnormality can be assumed to be the cause of the disturbance in spermiogenesis and to be associated with the formation of ...
O Knudsen
openalex   +2 more sources