Data from Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer [PDF]
Cancer Research, 2023 Abstract PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to targeting poly(ADP-ribose) generating PARP,
Zebin Wang +24 more
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Induction of Spindle Multipolarity by Centrosomal Cluster Inhibition [PDF]
Analytical Cellular Pathology, 2008 Version of ...
Alwin Krämer +2 more
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Testicular Hypoplasia with Multipolar Spindle Formation in the Spermiocytes of the Bull [PDF]
Acta Veterinaria Scandinavica, 1961 Formation of multipolar nuclear spindles in spermiocytes has been demonstrated in three highly in-bred and closely related bulls with a type of testicular hypoplasia which can be summarised as arrested spermiogenesis. The spindle abnormality can be assumed to be the cause of the disturbance in spermiogenesis and to be associated with the formation of ...
O Knudsen
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MULTIPOLAR SPINDLES IN HUMAN CANCER CELLS [PDF]
Hereditas, 2010 Eeva Therman, S Timonen
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Disturbed chromosome segregation and multipolar spindle formation in a patient with
Molecular Genetics & Genomic Medicine, 2017 Patients with intellectual disability (ID) typically exhibit significant defects in both intelligence and adaptive behavior. Aberration of several genes involved in proper progression of mitosis has been reported to underlie ID. Here, we report a new patient with a novel mutation of CHAMP1.Whole exome sequencing (WES) analysis was performed.
Nobuhiko Okamoto +6 more
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A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi‐1 [PDF]
Molecular Oncology, 2014 Traditional antimitotic drugs for cancer chemotherapy often have undesired toxicities to healthy tissues, limiting their clinical application. Developing novel agents that specifically target tumor cell mitosis is needed to minimize the toxicity and improve the efficacy of this class of anticancer drugs.
Jingnan Wang +6 more
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MULTIPOLAR SPINDLE 1 (MPS1), a novel coiled‐coil protein of Arabidopsis thaliana, is required for meiotic spindle organization [PDF]
The Plant Journal, 2009 SummaryThe spindle is essential for chromosome segregation during meiosis, but the molecular mechanism of meiotic spindle organization in higher plants is still not well understood. Here, we report on the identification and characterization of a plant‐specific protein, MULTIPOLAR SPINDLE 1 (MPS1), which is involved in spindle organization in meiocytes ...
Hua Jiang +9 more
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Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation [PDF]
Cell Cycle, 2013 Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor in certain types of cancer. It remains unknown whether parkin is involved in the development of pancreatic cancer, the fourth leading cause of cancer-related deaths worldwide.
Xiaodong Sun +10 more
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Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles [PDF]
Science Translational Medicine, 2014 The chemotherapy drug paclitaxel causes tumor regression and cell death by inducing high rates of chromosome missegregation on multipolar spindles.
Lauren M. Zasadil +8 more
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