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Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1. [PDF]

open access: yesProc Natl Acad Sci U S A
González-Fernández M   +4 more
europepmc   +1 more source

Induction of centrosome injury, multipolar spindles and multipolar division in cultured V79 cells exposed to dimethylarsinic acid: role for microtubules in centrosome dynamics

open access: closedMutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000
Role for microtubules in the induction of multiple microtubule organizing centers (MTOCs) and multipolar spindles by dimethylarsinic acid (DMAA), a methylated derivative of inorganic arsenics, was investigated with respect to the effects of microtubule disruption and reorganization.
Takafumi Ochi
semanticscholar   +4 more sources
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Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles.

Biochemical and Biophysical Research Communications, 2006
We previously identified a novel microtubule-destabilizing motif in CPAP that can disassemble microtubules. To examine further the CPAP function in human cells, we used siRNA to knockdown its expression. Our results showed that CPAP depletion arrested cells in mitosis and induced apoptosis.
Jun‐Hung Cho   +3 more
semanticscholar   +3 more sources

INDUCTION OF MULTIPOLAR SPINDLES BY X-RADIATION IN MAMMALIAN CELLS IN VITRO.

Experimental Cell Research, 1963
Coverslip cultures of mammalian cells in logarithmic growth were exposed to 200, 400, and 600 r x radiation and fixed at 12-hr intervals up to 108 hr after exposure. The generation time of untreated cells was about 24 hr. Mitotic figures were scored and classed according to their number of poles at different intervals after irradiation.
A. Levis, Guglielmo Marin
semanticscholar   +3 more sources

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