Results 201 to 210 of about 153,409 (229)
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Induction of multipolar spindles by single X-irradiated sperm
Experientia, 1959Une experience simple de dilution etablit que les clivages multipolaires des œufs de oursins resultent de l'insemination par des spermatozoides individuels qui ont ete soumis aux rayons X.
R. Rustad
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999
Inducibility of multipolar spindles and multipolar division by diethylstilbestrol (DES) and estradiol-17beta (E2) was investigated in terms of the mechanism of induction of aneuploidy by the estrogens. DES, E2 and bisphenol A (Bp-A), a structural analogue of DES, caused mitotic arrest and aberrant spindles, such as tripolar and multipolar spindles, in ...
T. Ochi
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Inducibility of multipolar spindles and multipolar division by diethylstilbestrol (DES) and estradiol-17beta (E2) was investigated in terms of the mechanism of induction of aneuploidy by the estrogens. DES, E2 and bisphenol A (Bp-A), a structural analogue of DES, caused mitotic arrest and aberrant spindles, such as tripolar and multipolar spindles, in ...
T. Ochi
semanticscholar +3 more sources
Chemosphere, 2016
The effects of bisphenol A (BPA), an endocrine chemical disruptor extensively used in the plastic and epoxy resin industry, on dividing root tip cells of the gymnosperm Abies cephalonica Loudon were investigated by confocal laser scanning microscopy after tubulin and endoplasmic reticulum immunolocalization and DNA staining.
I. Adamakis, E. Panteris, E. Eleftheriou
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The effects of bisphenol A (BPA), an endocrine chemical disruptor extensively used in the plastic and epoxy resin industry, on dividing root tip cells of the gymnosperm Abies cephalonica Loudon were investigated by confocal laser scanning microscopy after tubulin and endoplasmic reticulum immunolocalization and DNA staining.
I. Adamakis, E. Panteris, E. Eleftheriou
semanticscholar +3 more sources
, 2011 Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003
Dimethylarsine iodide (DMI) was used as a model compound of trivalent dimethylarsenicals [DMA(III)], and the biological effects were extensively investigated in cultured Chinese hamster V79 cells. When the cytotoxic effects of DMA(III) were compared with those of inorganic arsenite and dimethylarsinic acid [DMA(V)], DMA(III) was about 10,000 times more
T. Ochi +5 more
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Dimethylarsine iodide (DMI) was used as a model compound of trivalent dimethylarsenicals [DMA(III)], and the biological effects were extensively investigated in cultured Chinese hamster V79 cells. When the cytotoxic effects of DMA(III) were compared with those of inorganic arsenite and dimethylarsinic acid [DMA(V)], DMA(III) was about 10,000 times more
T. Ochi +5 more
semanticscholar +3 more sources
Mitotic spindle multipolarity without centrosome amplification
Nature Cell Biology, 2014Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell division. Multipolar spindles are often seen in human cancers and are usually associated with supernumerary centrosomes that result from centrosome overduplication or cytokinesis failure.
Helder, Maiato, Elsa, Logarinho
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Spindle Multipolarity Is Prevented by Centrosomal Clustering
Science, 2005Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity.
Nicholas J, Quintyne +4 more
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Science China Life Sciences, 2010
Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity.
M. Bian +7 more
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Paclitaxel is a widely used microtubule drug and cancer medicine. Here we report that by short exposure to paclitaxel at a low dose, multipolar spindles were induced in mitotic cells without centrosome amplification. Both TPX2 depletion and Aurora-A overexpression antagonized the multipolarity.
M. Bian +7 more
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Centrosomal amplification and spindle multipolarity in cancer cells
Seminars in Cancer Biology, 2005Recent developments have highlighted the important role centrosomal defects play in the cellular changes associated with tumorigenesis. This article reviews recent developments addressing the impact of numerical centrosomal amplification on chromosomal segregational defects in the cancer cell.
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